Synthesis, crystal structure, and urease inhibition studies of copper(II) and cobalt(III) complexes with bi(2-fluorobenzylaminoethyl)amine

Abstract

Three new mononuclear Cu(II) and Co(III) complexes [Cu(L)Cl]ClO 4 (1), [Cu(L)Cl(SCN)] (2), and [Co(L)(N 3 ) 3 ] (3), where L is a reduced Schiff-base ligand bi(2-fluorobenzylaminoethyl)amine, were synthesized and characterized. X-ray crystallographical analysis reveals that the Cu(II) atom adopts a square-planar environment in complex 1, while the geometry in 2 can be described as distorted square-pyramidal. The Co(III) atom in 3 is in a distorted octahedral geometry. Three complexes were investigated for their inhibitory activities in vitro against jack bean urease. The Cu(II) complexes 1 and 2 were found to have excellent inhibitory activities. The Co(III) complex 3 was also shown to have activity comparable to that of acetohydroxamic acid.

An Approach to Model the Active Site of Peptidglycine‐α‐hydroxylating monooxygenase (PHM)

“…In the literature only a few Cu II complexes with a N 3 X donor set are reported: [Cu II (L)Cl]ClO 4 (L = bis(2fluorobenzylaminoethyl)amine) from Dong et al [20] and [Cu II (PMDTA)Cl]PF 6 (PMDTA = pentamethyldiethylenetriamine) from Margraf et al [21] . Both complexes exhibit nearly regular square-planar coordination geometry.…”

Methylene bridge regulated geometrical preferences of ligands in cobalt(iii) coordination chemistry and phenoxazinone synthase mimicking activity

“…The careful inspection of literature reports shows that both facially and meridionally capped triazide cobalt(III) complexes are well known, and it is also noted that tripodal ligand systems exclusively yielded facial complexes, 46 while linear tridentate ligands favor the meridional arrangement. 35,36,47,48 But none of the reports dealt with the geometrical preferences of a ligand towards cobalt(III) by some sort of modification in ligand part. In the present report, we observed for the first time that just by a variation of the methylene spacer in one arm, diverse coordination patterns of the ligands in cobalt(III) complexes are achieved.…”

Schiff bases and their metal complexes as urease inhibitors – A brief review

“…It is also important to highlight the work of Pan and co-workers (2016) ( 42 and 43 ), Chen and co-workers ( 44 and 46), Habala and co-workers (2016) ( 45 ), Dong and co-workers (2011) ( 47 ), Cui and co-workers (2011) ( 48 ) and You and co-workers (2010) ( 49 ), who synthesized copper complexes with IC 50 values better than 1 µM, i.e., compounds with potent activities ( Fig. 7 ) [43] , [44] , [45] , [46] , [47] , [48] .

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“…On the other hand, Zn 2+ inhibited urease, but its complexes were inactive. Dong and co-workers also synthesized highly active Co complex 63 (IC 50 = 16.00 μM), and its anti-urease activity was attributed to its interaction with the metallic center and the sulfhydryl moieties of cysteine residue close to the enzyme’s active site [46] .

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