Synthesis, crystal structure and spectroscopic characterization of new anionic iridium(III) complexes and their interaction with biological targets

Anticancer Study on IrIII and RhIII Half-Sandwich Complexes with the Bipyridylsulfonamide Ligand

“…The above findings were also confirmed by the results of thermal denaturation studies (Figure ) of the DNA–Rh(III) complex reaction mixture (Δ T m = 3 °C). In contrast, the ligand itself can covalently interact with DNA via the nitrogen donor atoms of bipyridyl moiety as indicated by Δ T m equal to −6 °C in comparison with the value of the melting temperature for unbounded DNA ( T m = 84 ± 1 °C) …”

“…It should be noted that such a complete degree of neutralization in the case of organometallic complexes is relatively rare but noted in the literature. 80,101 In addition, the experimental data showed some differences between the iridium and rhodium complexes in terms of Cisplatin was used as a reference. b Cell lines: A-549�nonsmall lung cancer; MCF-7�breast cancer, Nalm-6�lymphoblastic leukemia; HCT-116�colon cancer; HEK293�nonmalignant human embryonic kidney.…”

“…103 Therefore, low affinity of complex 2 to GSH might be beneficial regarding its potential cytotoxic activity and corresponds well with results of antiproliferative assays. 99,101 As mentioned above, NADH also plays a vital role in the biocatalysis processes. The results obtained from UV−vis spectroscopy (Figures 9a and S25 in Supporting Information) for the reactions of analyzed compounds with NADH showed a noticeable decrease in the absorbance of the NADH band (339 nm) and an increase in the NAD + band (259 nm).…”

“…The best catalytic ability was noticed for the ligand (30.80 ± 0.95), which corresponds with the results of the MTT assay. 99,101 In Vitro Anticancer Activity Using MTT Assay. The antiproliferative activity against four cancer cell lines from different origins: nonsmall cell lung cancer A549, colon cancer HCT-116, breast cancer MCF7, leukemia Nalm-6, and a nonmalignant human embryonic kidney cell line HEK293 have been evaluated for the investigated compounds.…”

Stereoelectronic Profiling of Neutral and Monoanionic Biimidazoles and Mixed Diimines

“…On the other hand, 2,2′-biimidazole (H 2 biim) has garnered much popularity among the five-membered aromatic diimines due to its potential to coordinate as a neutral bidentate ligand or an anionic bridging ligand . The NH protons of the neutral biimidazole ligand can be exploited to form hydrogen bonds in supramolecular architectures or used in applications such as anion sensing. − Moreover, they can be deprotonated to bridge two or more metal ions. Hence, in extending the electronic profiling of 1,2-diimine ligands, we herein report the syntheses of palladium HEP2 complex probes with unsymmetrical mixed aryl diimines and symmetrical 2,2′-biimidazoles.…”