Synthesis, crystal structure and bovine serum albumin–binding studies of a new Cd(II) complex incorporating 2,2′-(propane-1,3-diyl)bis(1H-imidazole-4,5-dicarboxylate)

Abstract

A new Cd(II) complex, [Cd(H4pbidc)(H2O)] n (1), incorporating 2,2′-(propane-1,3-diyl)bis(1H- imidazole-4,5-dicarboxylic acid) (H6pbidc) was synthesized and characterized by elemental analysis, infrared spectra and X-ray single-crystal diffraction. In complex 1, each Cd(II) ion is hepta-coordinated, showing a significantly distorted pentagonal-bipyramidal coordination environment. Adjacent Cd(II) ions are alternately joined through two carboxylate oxygen atoms and two bridging water molecules resulting in a one-dimensional chain structure. In the solid state, adjacent chains are further linked by hydrogen bonds, forming a three-dimensional supramolecular architecture. Meanwhile, the interactions of complex 1 with bovine serum albumin were analysed by fluorescence measurements under physiological conditions. The results indicated that the fluorescence intensity of bovine serum albumin was decreased considerably upon the addition of complex 1 through a static quenching mechanism with formation of one binding site. The negative values of the thermodynamic parameters including enthalpy change (Δ H), entropy change (Δ S) and Gibbs free energy change (Δ G) showed that hydrogen bonding and van der Waals forces were the main interactions in the binding of complex 1 to bovine serum albumin, and the binding process is spontaneous in thermodynamics.

Crystal structure of catena-poly[diaqua(μ2-2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylato)cadmium(II)], C6H8CdN2O7

“…Each Cd1 ion is six-coordinated and located in a distorted octahedral CdN 2 O4 coordination environment formed by two N atoms (N1 and N2#1) and two O atoms (O4#1 and O5) from two H 2 hmIDC 2− anions and by two water molecules (O6 and O7). The Cd-O bond lengths range from 2.357(2) to 2.535(2) Å and the Cd-N bond lengths are 2.207(2) and 2.254(2) Å, respectively; these values are within the normal ranges and close to those reported in other Cd(II) complexes [13][14][15]. Cd(II) ions are linked by H 2 hmIDC 2− ligand into one-dimensional chains that run along the c axis.…”

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

“…Binding of serum protein with drug can be used to understand the targeted delivery and targeted release of drug molecules. Therefore, supervising the interaction of SA with latent bioactive compounds is not only of importance for drug screening in vitro, but it also affords a valuable theoretical direction for the synthesis of drug molecules [ 4 , 5 , 6 ]. In recent decades, a new interest in coordination compounds (CPs) therapy has emerged since CPs usually have better biological activity and pharmacological properties than the corresponding ligands [ 7 , 8 , 9 , 10 ].…”