2009
DOI: 10.1021/jf9029628
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Synthesis, Crystal Structure, and Biological Activity of 4-Methyl-1,2,3-thiadiazole-Containing 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazoles

Abstract: Heterocyclic compounds play an important role as the main sources of lead molecules of agrochemicals. Synthesis and biological activity of thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]-thiadiazoles were seldom reported. To find novel lead compounds with various biological activities, a series of 6-substituted-3-(4-methyl-1,2,3-thiadiazolyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadizoles were rationally designed and synthesized according to the principle of combinations of bioactive substructures by the condensa… Show more

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Cited by 112 publications
(93 citation statements)
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References 29 publications
(36 reference statements)
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“…[14]. Pyridine-2,6-dihydrazide (5 mmol, 0.98 g) was mixed with a solution of potassium hydroxide (20 mmol, 1.12 g) in anhydrous ethanol (30 mL) under stirring.…”
Section: Methodsmentioning
confidence: 99%
“…[14]. Pyridine-2,6-dihydrazide (5 mmol, 0.98 g) was mixed with a solution of potassium hydroxide (20 mmol, 1.12 g) in anhydrous ethanol (30 mL) under stirring.…”
Section: Methodsmentioning
confidence: 99%
“…Various isonicotinic acid derivatives like isonicotinyl hydrazides [32] , isonicotinamide derivatives [33] , 1,2,4-triazoles from isonicotinic acid hydrazide [34] , novel nalidixic acid derived 1,2,4-triazole [35] , 5-mercapto-1,2,4-triazole, novel 4H-1,2,4-triazol-3-yl-cycloalkanols [36] , new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles [37] , and diphenylamine containing 1,2,4-triazoles [38] , have been reported to possess diverse activity including antimicrobial and antitubercular. The therapeutic potential of 1,2,4-triazole prompted us to synthesize new compounds in which substituent could be arranged in a pharmacophoric pattern to display high order of antimycobacterial activity.…”
Section: Research Papermentioning
confidence: 99%
“…16 A stock solution of the title compound was prepared at 500 g/mL using sterilized water containing 2 drops of N ,N -dimethylformamide (DMF) as the solvent. Subsequently, 1 mL of the stock solution was transferred into a Petri dish with 10 cm in diameter, and 9 mL of PDA was added to prepare the plate containing 50 g/mL of the test compound.…”
Section: Fungicidal Experimentsmentioning
confidence: 99%