Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds

Salem, Adel Ben; Salah, Bochra Ben; Mhalla, Dhekra; Trigui, Mohamed; Mourer, Maxime; Regnouf-de-Vains, Jean Bernard; Kossentini, Mohamed

doi:10.1016/j.molstruc.2020.128209

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Amidrazones constitute a group of interesting compounds used mainly as precursors for the synthesis of five-, six- and seven-membered heterocyclic systems. Simple methods of obtaining 1,2,4-triazole, thiatriazole and 1,2,4-triazine derivatives [ 3 ], tetrazole [ 4 ] derivatives and other derivatives [ 1 ] from amidrazones have been described previously. Due to the presence of nitrogen atoms, amidrazones can form complexes with transition metals [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of the Biological Activity of Amidrazone Derivatives

et al. 2022

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Amidrazones are widely used in chemical synthesis, industry and agriculture. We compiled some of the most important findings on the biological activities of amidrazones described in the years 2010–2022. The data were obtained using the ScienceDirect, Reaxys and Google Scholar search engines with keywords (amidrazone, carbohydrazonamide, carboximidohydrazide, aminoguanidine) and structure strategies. Compounds with significant biological activities were included in the review. The described structures derived from amidrazones include: amidrazone derivatives; aminoguanidine derivatives; complexes obtained using amidrazones as ligands; and some cyclic compounds obtained from amidrazones and/or containing an amidrazone moiety in their structures. This review includes chapters based on compound activities, including: tuberculostatic, antibacterial, antifungal, antiparasitic, antiviral, anti-inflammatory, cytoprotective, and antitumor compounds, as well as furin and acetylocholinesterase inhibitors. Detailed information on the compounds tested in vivo, along the mechanisms of action and toxicity of the selected amidrazone derivatives, are described. We describe examples of compounds that have a chance of becoming drugs due to promising preclinical or clinical research, as well as old drugs with new therapeutic targets (repositioning) which have the potential to be used in the treatment of other diseases. The described examples prove that amidrazone derivatives are a potential source of new therapeutic substances and deserve further research.

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Section: Introductionmentioning

confidence: 99%

A Review of the Biological Activity of Amidrazone Derivatives

et al. 2022

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N-heterocycles: Recent Advances in Biological Applications

Dinodia

2023

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Nitrogen based heterocycles display an impressive repertoire of biological activities, including antioxidant, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, anti-viral, anti-HIV, anti-cancer, anti-helminthic, and other pharmacological activities. Numerous novel nitrogen-based heterocycles have been synthesized, which showed various physiological properties, and their application in medicinal chemistry is ever-growing. The present review will provide an in-depth view of N-heterocyclic compounds that showed biological activities in the last 5 years (2017-2021). This review article will be helpful for the structural design of effective and sustainable N-heterocyclic drugs against diseases with minimal side effects.

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Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds

Cited by 2 publications

References 26 publications

A Review of the Biological Activity of Amidrazone Derivatives

A Review of the Biological Activity of Amidrazone Derivatives

N-heterocycles: Recent Advances in Biological Applications

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