Synthesis, crystal structure and biological activity of two new heterotrinuclear thiocyanato bridged Cu(II)–Hg(II)–Cu(II) complexes

Yıldırım, Leyla Tatar; Kurtaran, Raıf; Namlı, Hilmi; Azaz, Ayşe Dilek; Atakol, Orhan

doi:10.1016/j.poly.2007.05.020

Cited by 46 publications

(12 citation statements)

References 18 publications

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“…Some experimentally structural data are available for the Schiffbase ligands [23][24][25] and especially Cu Salen complexes with 1,4-butanediamine N(CH 2 ) 4 N bridge [26][27][28][29][30]. Therefore, determination of structural parameters of the H 2 BS ligand and its Cu(II) complex is of great importance.…”

Section: Geometry Optimizationmentioning

confidence: 99%

Synthesis, experimental and theoretical characterization of N,N′-dipyridoxyl (1,4-butanediamine) Schiff-base ligand and its Cu(II) complex

Eshtiagh‐Hosseini

Housaindokht

Beyramabadi

et al. 2011

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Geometry Optimizationmentioning

confidence: 99%

Synthesis, experimental and theoretical characterization of N,N′-dipyridoxyl (1,4-butanediamine) Schiff-base ligand and its Cu(II) complex

Eshtiagh‐Hosseini

Housaindokht

Beyramabadi

et al. 2011

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…In more recent years there have been numerous reports highlighting the significant biological activity of Cu(II) Schiff base complexes [40][41][42][43][44][45][46]. Patil et al detailed the preparation of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole-derived coumarin Schiff bases and assessed their biological activity [47].…”

Section: Introductionmentioning

confidence: 99%

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Creaven

Devereux

Karcz

et al. 2009

Journal of Inorganic Biochemistry

101

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“…Based on the results of elemental analysis, IR, mass spectrometry, electronic spectra, magnetic moment, molar conductance measurements and thermogravimetric analysis, it may be concluded that Schiff base behaves as mononegative NO bidentate ligand, coordination occurring via the azomethine nitrogen and the deprotonated phenolic oxygen atom in position seven of the benzopyran-4-one ring, as shown in Schemes (2,3,4,5).…”

Section: Starink Methodsmentioning

confidence: 98%

“…Especially the complexes of Schiff bases with transition metals which have wide attention because of their diverse biological and pharmaceutical activities [1,2]. Schiff bases offer a versatile and flexible series of ligands capable of binding with various metal ions to give highly remarkable class of complexes having a wide range of applications [3][4][5][6]. So, the investigation of their interaction with various metal ions may contribute to a better understanding of their activities.…”

Section: Introductionmentioning

confidence: 99%

Complexes of Schiff base of benzopyran-4-one derivative

Abdel-Kader

Amin

El-Ansary

2015

J Therm Anal Calorim

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New metal complexes of Schiff base (L) prepared from condensation reaction of 2-aminopyridine and 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one with metal ions; Mn(II), Co(II), Ni(II) and Cu(II) are synthesized. Different analysis tools such as elemental analyses, FTIR, thermal analyses, conductivity, mass spectrometry, electronic spectra and magnetic susceptibility measurements are all used to elucidate the structures of the newly prepared metal complexes. The IR spectral data suggested that the ligand behaves as a monobasic bidentate ligand toward the central metal ion with ON donor atoms. The thermal decomposition kinetics of all complexes was estimated by Coats-Redfern. Ni-L and Co-L complexes were selected to study their thermal decomposition under non-isothermal conditions using Flynn-Wall-Ozawa and Starink methods at different three heating rates (5, 10 and 15°C min -1 ). The values of the activation energy (E) obtained by the all methods are in good agreement. All complexes are thermally stable as reflected from the high value of their activation energies. Ni-L complex has the highest thermal stability, and Mn-L complex has the lowest one indicating that Mn-L complex has fast rate of successive decomposition. The Schiff base L, Cu-L and Mn-L compounds were screened for in vitro cytotoxicity against normal standard fibroblast cells (3T3) using MTT assay. Among these compounds, Mn-L complex enhanced growth inhibition and cell death in a concentrationdependent manner for the standard fibroblast cells (3T3). Mn-L complex was then subjected against four human cancer cell lines; human hepatocellular carcinoma (Huh-7), human Hepatoblastoma (Hep G2) and human cervical cancer cells (HeLa & HeLa-Fas) for anticancer activity. Results indicate that Mn-L complex may be useful leads for anticancer drug development in the future.

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Synthesis, crystal structure and biological activity of two new heterotrinuclear thiocyanato bridged Cu(II)–Hg(II)–Cu(II) complexes

Cited by 46 publications

References 18 publications

Synthesis, experimental and theoretical characterization of N,N′-dipyridoxyl (1,4-butanediamine) Schiff-base ligand and its Cu(II) complex

Synthesis, experimental and theoretical characterization of N,N′-dipyridoxyl (1,4-butanediamine) Schiff-base ligand and its Cu(II) complex

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Complexes of Schiff base of benzopyran-4-one derivative

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