Synthesis, Crystal Structure and Antimicrobial Properties of an Anhydrous Copper(II) Complex of Pyridine-2-Carboxylic Acid

Abstract

A copper(II) complex with picolinic acid as ligand has been synthesised and characterised by elemental analysis, magnetic susceptibility, Fourier transform infrared spectroscopy (FTIR) and ultraviolet-visible spectroscopic techniques. The crystal structure of the complex has been determined by single crystal X-ray diffraction technique and the ligand was found to coordinate through N-and O-atoms. The ligand and the complex were screened for their activity against resistant strains of fungi (Candida albicans ATCC P37039, Candida albicans 194 B, Candida glabrata 44B, Cryptococcus neoformans) and bacteria (Staphylococcus aureus CIP 7625, Pseudomonas aeruginosa CIP 76110, Salmonella typhi and Escherichia coli ATCC 25922) isolated from humans in Cameroon.

Synthesis, Crystal Structure, and Antimicrobial Properties of [Diaquabis(hexamethylenetetramine)diisothiocyanato-κN]nickel(II) Complex

“…Mueller-Hinton Agar was employed as microbial growth medium. The antibacterial diffusion tests were carried out as previously reported [26].…”

Synthesis, Crystal Structure, and Antimicrobial Properties of a Novel 1-D Cobalt Coordination Polymer with Dicyanamide and 2-Aminopyridine

“…The activity of the complex towards the positive charge with the ligand's donor atoms so that there is electron delocalization within the metal complex. This may increase the hydrophobic and lipophilic character of the metal complex, enabling it to permeate the lipid layer of the organism killing them more effectively [39,40].…”

A Study of Metal Complexes of 2-picolinic Acid

“…A literature review on the subject of picolinic acid coordinate to the metal through nitrogen and carboxylate oxygen are most prominent [1][2][3][4] . The antimicrobial activities 5,6 of some metal complexes of the mixed ligands were reported [7][8][9][10][11][12][13][14][15] .…”