Synthesis, Computational Insights, and Anticancer Activity of Novel Indole–Schiff Base Derivatives

Significant Aspects of Heterocyclic Schiff Bases and Their Metal Complexes

“…The discussion pertaining to this chapter will purely be focused on the HSBs and related metal complexes containing at least one heterocyclic unit on either side of the imine group. Quite a few structural representations of HSBs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and some of their complexes (16)(17)(18)(19)(20)(21)(22)(23)(24) are shown in Figure 3.…”

“…The ability of indole-based Schiff bases as active anticancer agents has been exploited by Trivedi et al while they synthesized quite a few numbers of 3-substituted indole Schiff base derivatives consuming N-substituted indole-3-carboxaldehyde and substituted hydrazide (Figure 5) [9]. The anticancer activities of these compounds were tested against the A549 cell line (lung cancer) using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay and showed Significant Aspects of Heterocyclic Schiff Bases and Their Metal Complexes DOI: http://dx.doi.org/10.5772/intechopen.115087 moderate to excellent anticancer activity in comparison to the Osimertinib, a commercially available anticancer drug to treat lung cancer.…”

“…The anticancer activities of these compounds were tested against the A549 cell line (lung cancer) using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay and showed Significant Aspects of Heterocyclic Schiff Bases and Their Metal Complexes DOI: http://dx.doi.org/10.5772/intechopen.115087 moderate to excellent anticancer activity in comparison to the Osimertinib, a commercially available anticancer drug to treat lung cancer. Interestingly, the presence of furan ring in the Schiff base has produced better and remarkable results over other derivatives along with Osimertinib [9]. Thus, substituting suitable heterocycles for the R-group generates improved results than those obtained with non-heterocycles, signifying the importance of the heterocycles in the development of anticancer drugs.…”

Insight into Indole‐Based Heterocyclic Scaffolds: A Medicinal Chemistry Perspective

“…Among all compounds (18 b) and (18 g) were subjected to molecular docking studies and docked in binding site of E. coli DNA gysrase and C. albicans alpha lanosterol demethylase respectively and results were in accordance with in vitro antimicrobial activity results. (Scheme 3) Kunj M. Trivedi et al [24] developed a protocol for synthesis of new indole-Schiff base derivatives 23 (a-j). Initially indol-3carbaldehyde (19) and 4-(bromomethyl) benzonitrile (20) were reacted via to produce the compound, a nucleophilic substitution reaction was carried out at 90 °C with refluxing for 1 h in the presence of DMF and K 2 CO 3 .…”

“…Kunj M. Trivedi et al [24] . developed a protocol for synthesis of new indole‐Schiff base derivatives 23 (a–j) .…”