Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting Compounds

Abstract

Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting CompoundsSome [3,2-c]pyridine derivatives were synthesized. 3-(Furan-2-yl)propenoic acid (1a) was prepared from furan-2-carbaldehyde under the Perkin's conditions. Obtained acid was converted to the corresponding azide3, which in turn was cyclized to give furo[3,2-c]pyridin-4(5H)-one (4a). The reaction of pyridone4awith phosphorus oxychloride rendered the chloroderivative7a, which was treated in the condition of Suzuki coupling reaction with boronic acid to give 4-phenylfuro[3,2-c]pyridine (8e) and an unexpected product10. Some title compounds have shown moderate to good antimicrobial activity against tested bacteriaXanthomonas sp., Erwinia amylovora, and filamentous fungiPyrenophora avenae, Fusarium graminearum.