Synthesis, characterization, X-ray structures, and biological activity of some metal complexes of the Schiff base 2,2′-(((azanediylbis(propane-3,1-diyl))bis(azanylylidene))bis(methanylylidene))diphenol

Charef, Noureddine; Sebti, Fouzia; Arrar, Lekhmici; Djarmouni, Meriem; Boussoualim, Naouel; Baghiani, Abderrahmane; Khennouf, Seddik; Ourari, Ali; AlDamen, Murad A.; Mubarak, Mohammad S.; Peters, Dennis G.

doi:10.1016/j.poly.2014.09.006

Cited by 48 publications

(40 citation statements)

References 47 publications

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“…Schiff base metal complexes also find diverse and fruitful applications in industry and daily life [5][6][7][8][9][10]. There exist myriad reports on the biological activities of Schiff base ligands and their metal complexes, including their use for enzyme modeling, and catalytic activity and their function as antimicrobial, antifungal and antitumor agents [11][12][13][14][15]. It has been demonstrated that biological activities of these compounds are influenced significantly by metal coordination [16,17].…”

Section: Introductionmentioning

confidence: 99%

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

et al. 2018

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In this research, we prepared a new series of the Cu(II) (1) and Ni(II) (2) metal complexes of a tridentate Schiff base ligand, (E)-2-(5-bromo-2-hydroxybenzylideneamino) phenol (H 2 L). These complexes were characterized by elemental analysis, FT-IR, UV-Vis, and 1 H-NMR spectroscopy. The crystal structures of (1) and (2) were determined by X-ray diffraction studies. The single crystal X-ray diffraction analyses revealed that copper(II) cation is five-coordinated and the coordination polyhedron is a slightly distorted square pyramid. Nickel(II), on the other hand, is four-coordinated, and has a regular, square planar geometry. Further discussed were the electrochemical reduction of these complexes. We also analyzed the nature of the metal-ligand bond in the complexes through NBO and EDA analysis. Besides, vibrational sample magnetometer (VSM) revealed complex (1) was ferromagnetic.

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Section: Introductionmentioning

confidence: 99%

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

et al. 2018

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“…carbohydrates, peptides, lipids, vitamins, etc.). In addition, some diphenol Schiff base derivatives have high anti‐viral activities; however, several phenolic compounds possess anti‐microbial activity . Finally, a number of phenolic compounds seem to damage the cytoplasmic membrane in the presence of Cu (II) that is associated with the respective bactericidal activities …”

Section: Introductionmentioning

confidence: 99%

Characterization of bis‐Schiff bases synthesized using ZnFe₂O₄ nanoparticles as catalyst, and examination of their antibacterial and in vitro cytotoxic properties

Maaref

Sheikhhosseini

Foroughi

et al. 2020

Applied Organom Chemis

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In this study, ZnFe2O4 nanoparticles (NPs) were prepared by a hydro/solvothermal method, and their structures were characterized by infrared, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy and X‐ray diffraction analyses. These ZnFe2O4 NPs were used in the synthesis of new bis‐Schiff bases by condensation of hydroxyl‐substituted aldehydes with various aromatic diamines in aqueous media. The antimicrobial activities of the synthesized bis‐Schiff bases were tested against gram‐negative as well as gram‐positive bacteria. The MTT method was used to assess the anticancer activity of the bis‐Schiff bases towards human lung and breast cancer cell lines. The results indicated that these compounds could be considered as new anti‐tumor candidates.

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“…Anticancer activity is one of the most attractive applications involved the examination in capability of coordination compounds in biological studies. Silver(I) complexes was found to be the most effective substrate in antibacterial and antifungal studies for several years (Kumar et al,2010;Chandra and Ruchi, 2013;Charef et al, 2015. Our recent research also revealed that silver(I) complexes incorporated with the mixed ligands of triphenylphosphine and acesulfame exhibit excellent activity against A549 lung cancer cells (Boonseng et al, 2018). Herein, we would like to expand the scope of metals to the first-row transition metals; nickel(II) and copper(II) which has been prevalently used for numerous catalysis and biological studies (Chandra et al, 2015;Ghobadi et al, 2018;Mo et al, 2018;Saha et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Metal Complexes with Acesulfame Mixed with Triphenylphosphine Ligands

Boonseng¹,

Khudkham²,

Wongsuwan³

et al. 2019

CMUJNS

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Metal complexes of silver(I), nickel(II) and copper(II) with the mixed ligands of acesulfame (ace) and triphenylphosphine (PPh 3) were prepared in this work. The complexes of [Ag(ace)] n (1), [Ag(ace)(PPh 3)] (2), [Ni(ace) 2 (H 2 O) 4 ] (3),[Ni(ace) 2 (PPh 3) 2 ] (4), [Cu(ace) 2 (H 2 O) 2 ] (5) and [Cu(ace) 2 (PPh 3) 2 ] (6) were characterised by FT-IR and NMR spectroscopy, Mass spectrometry including X-Ray powder diffraction. The synthesised complexes were examined in their anticancer activity against A549 lung cancer cells which were further evaluated their efficiency by IC 50 method. [Ag(ace)] n (1), [Ni(ace) 2 (H 2 O) 4 ] (3) and [Cu(ace) 2 (H 2 O) 2 ] (5) which contain only acesulfame ligand exhibited higher IC 50 values in comparison to the mixed ligands of ace and PPh 3. [Ag(ace)(PPh 3)] (2), [Ni(ace) 2 (PPh 3) 2 ] (4) and [Cu(ace) 2 (PPh 3) 2 ] (6) displayed the inhibition in the growth of cancer cells with IC 50 values of 1.65, 13.45 and 1.06 µM, respectively. Additionally, silver(I) and copper(II) complexes also presented better activity than the standard Etoposide (IC 50 5.623 µM). The results indicated that the mixed ligands could perform more excellent inhibition of cancer cells growing in comparison to the using of only acesulfame or triphenylphosphine ligand.

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Synthesis, characterization, X-ray structures, and biological activity of some metal complexes of the Schiff base 2,2′-(((azanediylbis(propane-3,1-diyl))bis(azanylylidene))bis(methanylylidene))diphenol

Cited by 48 publications

References 47 publications

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

Characterization of bis‐Schiff bases synthesized using ZnFe₂O₄ nanoparticles as catalyst, and examination of their antibacterial and in vitro cytotoxic properties

Anticancer Activity of Metal Complexes with Acesulfame Mixed with Triphenylphosphine Ligands

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Synthesis, characterization, X-ray structures, and biological activity of some metal complexes of the Schiff base 2,2′-(((azanediylbis(propane-3,1-diyl))bis(azanylylidene))bis(methanylylidene))diphenol

Cited by 48 publications

References 47 publications

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

Characterization of bis‐Schiff bases synthesized using ZnFe2O4 nanoparticles as catalyst, and examination of their antibacterial and in vitro cytotoxic properties

Anticancer Activity of Metal Complexes with Acesulfame Mixed with Triphenylphosphine Ligands

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Characterization of bis‐Schiff bases synthesized using ZnFe₂O₄ nanoparticles as catalyst, and examination of their antibacterial and in vitro cytotoxic properties