Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure–activity correlation

Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)].

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“…The values were found to be in the range of 30.1–38.8 μ Scm −1 suggesting the nonelectrolytic nature of the complexes in solution [22, 29]. …”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

Ejidike

Ajibade

2016

Bioinorganic Chemistry and Applications

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“…The molar conductivity (Λμ) values of the Ru(III) complexes in 10 −3 M DMF solution (table 1) at room temperature are 23.8-47.4 μS cm −1 , indicating the essential non-electrolytic character of the compounds [1,58].…”

Section: Molar Conductivity Measurementsmentioning

confidence: 99%

“…Synthesis of biologically active molecules is a vigorous task and the variables affecting biological activity are diverse [1][2][3][4]. Many studies on the molecular structure of metal complexes and their bioactivity have created much awareness in the field of bio-inorganic chemistry [5,6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, andin vitroantioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases

Ejidike

Ajibade

2015

Journal of Coordination Chemistry

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To cite this article: Ikechukwu P. Ejidike & Peter A. Ajibade (2015): Synthesis, characterization, and in vitro antioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases, Journal of Coordination Chemistry, Ruthenium(III) complexes of three tetradentate Schiff bases with N 2 O 2 donors formulated as [RuCl (LL 1 )(H 2 O)], [RuCl(LL 2 )(H 2 O)] and [RuCl(LL 3 )(H 2 O)] were synthesized and characterized by elemental analyses, molar conductance, FTIR, and electronic spectral measurements. The FTIR data showed that the tetradentate Schiff base ligands coordinate to Ru ions through the azomethine nitrogen and enolic oxygen. The antioxidant activities of the complexes were investigated through scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. The DPPH activity for [RuCl(LL 2 )(H 2 O)] with IC 50 = 0.031 mg mL −1 was higher than the values obtained for the other Ru(III) compounds. The study revealed that the synthesized Ru(III) complexes of the tetradentate Schiff base exhibited strong scavenging activities against DPPH and moderate against ABTS radicals. In addition, the antiproliferative studies of the complexes were also tested against human renal cancer cells (TK10), human melanoma cancer cells (UACC62), and human breast cancer cells (MCF7) using the SRB assay. The results indicated that the Ru(III) complexes showed low anticancer activities against the tested human cancer cell lines.

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“…5 Regarding the DNA interaction with Ni(II) complexes showed intercalative behavior and also DNA cleavage ability. 6 In our previous studies a series of mixed-ligand Cu(II) coordination compounds, with bidentate, tridentate and polydentate amines and their Schiff bases, 7,8 trihalides, 9 1,2-dithiolates, 10 and 1,3-thiazoles, thiazolines and imidazole [11][12][13][14] have been utilized as models to investigate their toxicity, 10,12 anti-inflammatory activity, 12 antimicrobial activity against Gram(+) and Gram(À) bacteria 9,11,14 and anti-proliferative activity in vitro 9,11,13,14 and in vivo 10,12 towards various cancer cell lines, for example, HeLa, T47D, HT-29, MCF7, MRC5 and P388 leukemia. A relationship between medicinal effectiveness and physicochemical, structural properties of the ligands and their Cu(II) complexes, have been carried out.…”

Section: Introductionmentioning

confidence: 99%

Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt)2]

Cox¹,

Psomas²,

Bolos³

2009

Bioorganic & Medicinal Chemistry

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Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure–activity correlation

Cited by 32 publications

References 30 publications

Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

Synthesis, characterization, andin vitroantioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases

Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt)2]

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