Synthesis, characterization, thermal study and biological evaluation of Cu(II), Co(II), Ni(II) and Zn(II) complexes of Schiff base ligand containing thiazole moiety

Yernale, Nagesh Gunavanthrao; Raj, K. Mahendra; Mruthyunjayaswamy, B. H. M.

doi:10.1016/j.molstruc.2014.09.013

Cited by 95 publications

(33 citation statements)

References 34 publications

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“…Transition metal complexes derived from Schiff base ligands are one of the most exhaustively studied topic in coordination chemistry, due to their enhanced activities compared to other complexes . Schiff base complexes show important physiological and pharmacological activities due to their favorable cell membrane permeability .…”

Section: Introductionmentioning

confidence: 99%

Molecular modeling, spectral investigation and thermal studies of the new asymmetric Schiff base ligand; (E)‐N'‐(1‐(4‐((E)‐2‐hydroxybenzylideneamino)phenyl)ethylidene)morpholine‐4‐carbothiohydrazide and its metal complexes: Evaluation of their antibacterial and anti‐molluscicidal activity

El-Samanody

Abouel‐Enein

Emara

2018

Applied Organom Chemis

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A new tetradentate asymmetric Schiff base ligand; (E)-N'-(1-(4-((E)-2hydroxybenzylideneamino)phenyl)ethylidene)morpholine-4-carbothiohydrazide (H 2 L) was prepared by consecutive condensation reactions between p-aminoacetophenone, salicylaldehyde and 4-morpholinethiosemicarbazide. The structures of the obtained ligand along with its Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Cr(III), Fe(III) and Ru(III) complexes were authenticated by different analytical and spectral techniques. The ligand behaves as a monobasic tetradentate one and chelates with metal ions through the deprotonated phenolic oxygen, imine nitrogen, thione sulfur and azomethine nitrogen atoms (ONNS chromophore). All nonelectrolyte metal complexes possess octahedral geometry, except Ni(II) and Cu(II) complexes (2, 3) which have tetra-coordinate structures. The thermal stability of metal complexes is higher than that of the free ligand and the general thermal degradation pathways were discussed based on thermogravimetric technique. The activation thermodynamic parameters as well as the order of reaction (n) were estimated from DTG curves by using Piloyan method. Thermogravimetric analyses and mass spectra of metal complexes confirm the number of solvents in their inner and outer spheres.Molecular modeling data were used to demonstrate the thermal decomposition pathways of the ligand and its metal complexes, confirming their chemical structures. The ESR spectra of Cu(II) complexes indicate that the unpaired electron is localized mainly in the d (x 2 -y 2 ) orbital with axial symmetry. Powder X-ray diffraction analyses for Co(II), Cu(II) and Ru(III) complexes (1,3,7) show that copper complex has a crystalline nature, whereas, cobalt and ruthenium complexes are amorphous. The ligand and its metal complexes were tested in vitro for their anti-molluscicidal activity against Eobania vermiculata. The results reveal that the investigated compounds have remarkable antimolluscicidal activities against the tested land snail with various sensitivity levels. The synthesized compounds were also screened in vitro for their

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Section: Introductionmentioning

confidence: 99%

Molecular modeling, spectral investigation and thermal studies of the new asymmetric Schiff base ligand; (E)‐N'‐(1‐(4‐((E)‐2‐hydroxybenzylideneamino)phenyl)ethylidene)morpholine‐4‐carbothiohydrazide and its metal complexes: Evaluation of their antibacterial and anti‐molluscicidal activity

El-Samanody

Abouel‐Enein

Emara

2018

Applied Organom Chemis

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“…Recently we have reported the synthesis, characterization and biological activities of some metal (II) complexes of Schiff bases containing thiazole, benzo [b]thiophene and quinoline moieties [17][18][19]. Exhilarated by these reports, we have synthesized the novel Schiff base ligand 2-((2-hydroxynaphthalen-1-yl) methylene)-N-(4-phenylthiazol-2-yl) hydrazinecarboxamide (L) containing carbonyl, azomethines and hydroxyl groups as potential chelating sites.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological relevance of some metal (II) complexes with oxygen, nitrogen and oxygen (ONO) donor Schiff base ligand derived from thiazole and 2-hydroxy-1-naphthaldehyde

Yernale

Mruthyunjayaswamy

2015

Journal of Molecular Structure

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“…The diffractogram and associated data depict the 2θ value, relative intensity and inter‐planar spacing (d‐values). In complexes 7‐9, the trend of the curves decreased from maximum to minimum intensity indicating the amorphous nature of the complexes …”

Section: Resultsmentioning

confidence: 99%

Green synthesis of biologically active transition metal nanoparticles containing novel Schiff base via catalyst free hydrothermal reaction: Structural, biological and morphology study

Jawoor

Kumbar

Patil

2018

Applied Organom Chemis

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Novel cobalt, nickel and copper complexes were synthesized by regular reflux method and nano sized Co(II), Ni(II) and Cu(II) metal complexes were synthesized by a facile hydrothermal method using green solvent at various temperatures without the addition of any capping agent. The structural characterization was done by magnetic susceptibility, molar conductance, elemental analysis, thermal analysis, FT-IR, 1 H NMR, 13 C NMR, ESI mass, UV-Visible analysis. The morphology and size of the nano metal complexes were determined using FE-Scanning electron microscopy, powder X-ray diffraction data and atomic force microscopic techniques. All the spectral and analytical results reveal 1:2 metal to ligand ratios having [ML 2 (H 2 O) 2 ] stoichiometry, here M=Co(II), Ni (II) and Cu(II), L=deprotonated ligand. The non-electrolytic nature of the compound was confirmed by molar conductance experiment. The synthesized Schiff base and its metal complexes (7, 8 and 9) were tested for their biological activity. All the tested compounds exhibit decent anticancer and DNA cleavage activity and copper complex shows better activity results than other tested compounds.

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Synthesis, characterization, thermal study and biological evaluation of Cu(II), Co(II), Ni(II) and Zn(II) complexes of Schiff base ligand containing thiazole moiety

Cited by 95 publications

References 34 publications

Synthesis, characterization and biological relevance of some metal (II) complexes with oxygen, nitrogen and oxygen (ONO) donor Schiff base ligand derived from thiazole and 2-hydroxy-1-naphthaldehyde

Green synthesis of biologically active transition metal nanoparticles containing novel Schiff base via catalyst free hydrothermal reaction: Structural, biological and morphology study

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