Synthesis, characterization, thermal, DFT computational studies and anticancer activity of furfural-type schiff base complexes

Effective corrosion inhibition of mild steel in hydrochloric acid by newly synthesized Schiff base nano Co(ii) and Cr(iii) complexes: spectral, thermal, electrochemical and DFT (FMO, NBO) studies

“…37 The bands at 1650 cm −1 and 1570 cm −1 could be assigned to the stretching vibrations of v (CO) carboxyl and v (CN) azomethine of the free HL. 30,36–40 In contrast, the absence of a band at 1650 cm −1 in the complexes' spectra in addition to a red shift in the characteristic wavenumber of the azomethine group to 1558 cm −1 for Co( ii ) and 1557 cm −1 for Cr( iii ) indicates that the v (CO) carboxyl and v (CN) azomethine groups were involved in the interaction with metal ions. 37 A ligand having a carboxylate group can undergo coordination with metal ions in three different modes: mono-dentate, bi-dentate, and a bridge one.…”

“…Moreover, the lack of a signal owing to the –OH proton at 12.34 ppm shows that the hydroxyl group of the carboxylic group was deprotonated during complex formation. 37–40 The complexes' 1 HNMR spectra indicated a signal in the 8.46 ppm area which is related to the azomethine (–NCH–) proton. 38,39 Furthermore, the shift of the azomethine (–CN–) carbon signal within the complex spectra relative to that of ligand spectrum, clearly suggests that the azomethine moiety was engaged in the coordination.…”

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

“…In this case, the oxygen and nitrogen atoms on the sulfisoxazole ring, the oxygen atom of sulfonyl groups and oxygen and nitrogen atoms attached to the benzene ring are thought to be involved in the hydrogen bonds' formation. Ismail et al (2021) [49] studied several complexes in which the N 1 ,N 2 -bis(furan-2-ylmethylene)-4-methylbenzene-1,2-diamine (L) is complexed with several metals, namely Ag(I), Cr(III), Fe(III), Co(II), Cu(II) and Cd(II) (13)(14)(15)(16)(17)(18), and studied their cytotoxicity against the HepG2 cell lines. The IC 50 values were 12.9 µg/mL, 14.8 µg/mL, 7.31 µg/mL, 8.53 µg/mL, 17.1 µg/mL and 1.95 µg/mL, respectively.…”

“…Cl (15) IC50 = 7.31 μg/mL Ismail et al (2021) [49] [CrLNO 3 (H 2 O)]2NO 3 . 2H 2 O (14) IC 50 = 14.8 µg/mL, Ismail et al (2021) [49] NO3 (13) IC50 = 12.9 μg/mL Ismail et al (2021)[49] …”

Chemical Characterization and Biological Evaluation of New Cobalt(II) Complexes with Bioactive Ligands, 2-Picolinehydroxamic Acid and Reduced Schiff Base N-(2-Hydroxybenzyl)alanine, in Terms of DNA Binding and Antimicrobial Activity

“…In addition, they are used for the liquid membrane transport of metal cations, liquid-liquid extraction and as catalysts [31]. Schiff base complexes possess antifungal [32] and antibacterial [1,33] properties and can bind to DNA [34], as well as antitumor activity, influenced by the presence of an electron withdrawing group in the benzene ring [20,35]. Heterocyclic compounds containing pyridine and its related compounds, such as PicHA, offer promise as biological ligands due to the presence of a ring nitrogen with a localized pair of electrons.…”