Synthesis, Characterization, Thermal, and Antibacterial Studies of Organotin(Iv) Complexes of Indole-3-Butyric Acid and Indole-3-Propionic Acid

Chilwal, Asha; Malhotra, Priti; Narula, Anudeep Kumar

doi:10.1080/10426507.2013.819871

Cited by 25 publications

(16 citation statements)

References 33 publications

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“…For the present complexes, there is no sharp weight loss displayed in the TG curves and the recommended percentage mass loss in three steps which ended with the formation of respective metal oxides as residue was observed. The results showed that there is a fine agreement in the weight loss between the calculated values and the proposed formulae …”

Section: Resultsmentioning

confidence: 68%

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Devi

Yadav

Kumar

et al. 2018

Applied Organom Chemis

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Mononuclear transition metal(II) complexes of the type M(L)2⋅2H2O (where M = Co, Ni, Cu, Zn) have been synthesized from uninegative Schiff base ligands (HL1–HL4) designed by condensation of 4‐fluorobenzylamine with 2‐hydroxy‐1‐naphthaldehyde/3,5‐dichlorosalicylaldehyde/3,5‐dibromosalicylaldehyde/3‐bromo‐5‐chlorosalicylaldehyde. The compounds were successfully characterized using spectroscopic and physiochemical methods together with elemental analysis. Spectroscopic elucidation indicates a monobasic bidentate nature of ligands coordinated via deprotonated phenolic oxygen and azomethine nitrogen atom which suggests an octahedral geometry around the central metal ions. The complexes and ligands were screened for their in vitro antimicrobial activity against bacterial and fungal strains, the zinc(II) complexes being more active against the tested microbial strains. Further, the metal complexes were found to be more active than the uncomplexed ligands due to chelation process and, moreover, the complexes were more active against fungal strains than bacterial strains. Cytotoxic activities of all compounds were evaluated towards human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and one normal human lung cell line (MRC‐5) using MTT colorimetric assay with doxorubicin as a standard. The zinc complexes were most active against the cancer cell lines and also found to be less toxic against MRC‐5 normal cell line than standard doxorubicin.

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Section: Resultsmentioning

confidence: 68%

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Devi

Yadav

Kumar

et al. 2018

Applied Organom Chemis

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“…The first step of decomposition corresponds to the loss of two methyl groups attached to tin. The second step of decomposition corresponds to the loss of ligand moiety along with the formation of SnO 2 as final residue …”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, and quantitative structure–activity relationship studies of bioactive dehydroacetic acid and amino ether Schiff base complexes

Devi

Kumar

2016

Heteroatom Chemistry

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Structural aspects of organosilicon(IV) and organotin(IV) complexes with dehydroacetic acid and amino ether Schiff base ligand have been described with the help of elemental analyses, conductance measurements, UV–Vis, infrared, multinuclear magnetic resonance, mass spectroscopy as well as thermogravimetric analysis, and X‐ray diffraction studies. Analysis of data suggested that the Schiff base provides two bidentate NO domains and was coordinated to silicon and tin moiety through the imine nitrogen and hydroxyl oxygen atom. Complexes were found to be nonelectrolytic and monomeric in nature. The thermal decomposition for tin compounds occurred in two steps and resulted into the formation of pure SnO2 as end product. The in vitro biological effects of the synthesized compounds were tested against two Gram‐positive and two Gram‐negative bacteria. The results of biological activity showed that all the complexes have enhanced activity as compared with the corresponding ligand, and compounds 5, 9, 11, 12, 13, 15, 16, and 17 were more potent than the standard drug ciprofloxacin. Compound 17 exhibited best antibacterial activity with lowest minimum inhibitory concentration value and maximum zone of inhibition. Further, quantitative structure–activity relationship studies pointed out that more stable compound were more active as antibacterial agents.

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“…Discovery of cis-platin by Rosenberg [55] and its new marketing analogues (carboplatin, lobaplatin, oxaliplatin, nedaplatin) have further created interest in metal-based anticancer drugs [1,56]. Tin complexes have been studied in detail as antibacterial agents [9,15,[17][18][19]28] and recently against cancerous cell lines [12,26,57] other than colon cancer. In the current study, complexes 1-2 were tested against three cancerous cell lines (human colon cancer HCT 116, breast cancer MCF-7, leukemia K562) and a non-cancerous cell line (3T3-L1).…”

Section: In Vitro Anticancer Studiesmentioning

confidence: 98%

“…Tin is a non-transition and biocompatible metal [5][6][7] and its complexes have shown significant antibacterial properties [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. However, tin complexes have been rarely studied against cancer [12,[23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures and spectroscopic properties of two new organotin (IV) complexes and their antiproliferative effect against cancerous and non-cancerous cells

Win

Choong

Dang

et al. 2015

Comptes Rendus. Chimie

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Synthesis, Characterization, Thermal, and Antibacterial Studies of Organotin(Iv) Complexes of Indole-3-Butyric Acid and Indole-3-Propionic Acid

Cited by 25 publications

References 33 publications

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Synthesis, characterization, and quantitative structure–activity relationship studies of bioactive dehydroacetic acid and amino ether Schiff base complexes

Synthesis, crystal structures and spectroscopic properties of two new organotin (IV) complexes and their antiproliferative effect against cancerous and non-cancerous cells

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