Synthesis, characterization, theoretical studies and antioxidant and cytotoxic evaluation of a series of Tetrahydrocurcumin (THC)-benzylated derivatives

Alvarez-Ricardo, Yair; Meza-Morales, William; Obregón‐Mendoza, Marco A.; Toscano, Rubén A.; Núñez‐Zarur, Francisco; Germán-Acacio, Juan Manuel; Puentes-Díaz, Nicolás; Alí‐Torres, Jorge; Arenaza‐Corona, Antonino; Ramírez‐Apán, María Teresa; Morales‐Morales, David; Enríquez, Raúl G.

doi:10.1016/j.molstruc.2022.134355

Cited by 3 publications

(3 citation statements)

References 50 publications

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“…However, more evidence is required to support their antidepressant effects, as well as stricter regulations in the production and characterization of these natural compound. Likewise, further studies are needed to test whether the antioxidant effects of these natural compounds and antidepressant drugs are sufficient to support Higher total antioxidant intake was significantly associated with lower odds of depression along with improvements in depression and anxiety conditions, further confirming the therapeutic potential of antioxidant supplements as adjunctive therapy to conventional antidepressants [29,30]. L-histidine intake may improve cognitive function (e.g., reducing appetite, anxiety, and stress responses and improving sleep quality) potentially through the metabolism of histidine to histamine; however, this relationship remains ambiguous in humans.…”

Section: Findings and Discussionmentioning

confidence: 99%

Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression

Aini Dania,

Rusdiana,

S. Rambe

et al. 2024

QAJ

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This study examined compound active of red ginger related for supplementation and treatment of depression. Depression prevalence in Indonesia from the national population survey 6.9% had severe depression symptoms, 21.8% moderate to severe. Red ginger provided gold potential and demonstrated prominent natural phenomena and coexistence, abundant benefits. Standard herbal medicine and phytopharmaceuticals as one effort in dealing with depression disorder. Problem Statement. The use of medicines for depression disorder in the long term becomes a serious problem affecting various sectors and needs to be thought of side effects and complications. Objective. Antioxidants in red ginger (Zingiber Officinale Rosc. Var Rubrum has a secondary metabolite considered for treatment or supplementation in depression disorders. This study was experimental analytical study for analyzing secondary metabolism using phytochemical screening tests and examining active compounds with the combination of liquid chromatography with tandem mass spectrometry (LCMS/MS).Red ginger extracts contain secondary metabolic flavonoids of 48.79 mgQE/g, phenol 92.73 mgGAE/G and antioxidants of 39.96 ppm. Establishment of the active compound that has an effect as an antioxidant α-Eleostearic acid (C18 H30 O2) chemspider result 10, mzcloud 96, L Histidine (C6 H9 N3 O2) chemspiders result 6, mzcloud 94,8. Tetrahydrocurcumin (C21 H24 O6) chemspider result 41, mzcloud 92,5. Active compounds of red ginger antioxidants are diarylheptanoid, phenylbutenoid, flavonoid, diterpenoide, sesquiterpenoid, gingerol and shogaol. Red ginger extract content of active flavonoid compounds and has an effect as an antioxidant is potentially used as a supplement in the treatment of depression disorders.

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Section: Findings and Discussionmentioning

confidence: 99%

Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression

Aini Dania,

Rusdiana,

S. Rambe

et al. 2024

QAJ

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“…Curcumin, a type of β-dicarbonyl compound and the main ingredient of the rhizome of Curcuma longa L., has attracted considerable attention in the pharmaceutical and medical community because of its versatile biological properties. 1–7 In the enol form, β-dicarbonyl compounds possess intramolecular hydrogen bonds. In particular, the intramolecular hydrogen bond in curcumin can be classified as a low-barrier hydrogen bond (LBHB), which is a hydrogen bond with an extremely low-energy barrier for proton transfer.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from experimental studies, theoretical studies have been conducted. 5–7 Kong et al conducted a classical molecular dynamics (CLMD) study on curcumin to analyze the proton probability distribution in an intramolecular LBHB. The energy barrier of an LBHB is very low and can be easily overcome by thermal and nuclear quantum effects (NQEs).…”

Section: Introductionmentioning

confidence: 99%

Nuclear quantum and H/D isotope effects on intramolecular hydrogen bond in curcumin

Udagawa

Yabushita

Tanaka

et al. 2023

Phys. Chem. Chem. Phys.

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Synthesis, spectroscopic analysis, DFT, docking, MD and antioxidant activity of tetrahydrocurcumin

Qiu,

Wang,

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Synthesis, characterization, theoretical studies and antioxidant and cytotoxic evaluation of a series of Tetrahydrocurcumin (THC)-benzylated derivatives

Cited by 3 publications

References 50 publications

Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression

Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression

Nuclear quantum and H/D isotope effects on intramolecular hydrogen bond in curcumin

Synthesis, spectroscopic analysis, DFT, docking, MD and antioxidant activity of tetrahydrocurcumin

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