Synthesis, Characterization, Swelling, and Metal Uptake Studies of Aryl Cross-Linked Chitosan Hydrogels

Tımur, Mahir; Paşa, Ahmet

doi:10.1021/acsomega.8b01872

Cited by 49 publications

(23 citation statements)

References 50 publications

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“…However, CS coatings showed maximum swelling behavior, which reduced with an increasing amount of Cu(II). In the case of CS coatings, the hydrogen bonding with water and free NH 2 groups of CS play a main role in the swelling process [44]. The electronegative covalent bonds (N-H) create sites of high polarity that support the rearrangement of water molecules around them [45].…”

Section: Swelling Ratiomentioning

confidence: 99%

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Akhtar

Ilyas

Dlouhý

et al. 2020

IJMS

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Bacterial infection associated with medical implants is a major threat to healthcare. This work reports the fabrication of Copper(II)–Chitosan (Cu(II)–CS) complex coatings deposited by electrophoretic deposition (EPD) as potential antibacterial candidate to combat microorganisms to reduce implant related infections. The successful deposition of Cu(II)–CS complex coatings on stainless steel was confirmed by physicochemical characterizations. Morphological and elemental analyses by scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) spectroscopy verified the uniform distribution of copper in the Chitosan (CS) matrix. Moreover, homogeneous coatings without precipitation of metallic copper were confirmed by X-ray diffraction (XRD) spectroscopy and SEM micrographs. Controlled swelling behavior depicted the chelation of copper with polysaccharide chains that is key to the stability of Cu(II)–CS coatings. All investigated systems exhibited stable degradation rate in phosphate buffered saline (PBS)–lysozyme solution within seven days of incubation. The coatings presented higher mechanical properties with the increase in Cu(II) concentration. The crack-free coatings showed mildly hydrophobic behavior. Antibacterial assays were performed using both Gram-positive and Gram-negative bacteria. Outstanding antibacterial properties of the coatings were confirmed. After 24 h of incubation, cell studies of coatings confirms that up to a certain threshold concentration of Cu(II) were not cytotoxic to human osteoblast-like cells. Overall, our results show that uniform and homogeneous Cu(II)–CS coatings with good antibacterial and enhanced mechanical stability could be successfully deposited by EPD. Such antibiotic-free antibacterial coatings are potential candidates for biomedical implants.

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Section: Swelling Ratiomentioning

confidence: 99%

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Akhtar

Ilyas

Dlouhý

et al. 2020

IJMS

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“…The abundant functional groups (-NH 2 and -OH) of CHT are amenable for modification ( Figure 1) by physical and chemical means. Cross-linking is a versatile method for modification of chitosan, where the degree of cross-linking in composite materials affects the range of swelling, mechanical, and adsorption properties [25]. In the case of biopolymer composites that contain chitosan and PANI, there is limited covalent cross-linking between polyaniline and chitosan, whereas hydrogen bond formation occurs between the -OH or -NH 2 groups of chitosan and the imine/amine (=N-or -NH-) groups of PANI ( Figure 1b).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Multicomponent Biocomposites and Characterization of Their Physicochemical and Mechanical Properties

2020

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This work focused on a mutual comparison and characterization of the physicochemical properties of three-component polymer composites. Binary polyaniline–chitosan (PANI–CHT) composites were synthesized by in situ polymerization of PANI onto CHT. Ternary composites were prepared by blending with a third component, polyvinyl alcohol (PVA). Composites with variable PANI:CHT (25:75, 50:50 and 75:25) weight ratios were prepared whilst fixing the composition of PVA. The structure and physicochemical properties of the composites were evaluated using thermal analysis (thermogravimetric analysis (TGA), differential scanning calorimetry (DSC)) and spectroscopic methods (infrared (IR), nuclear magnetic resonance (NMR)). The equilibrium and dynamic adsorption properties of composites were evaluated by solvent swelling in water, water vapour adsorption and dye adsorption isotherms. The electrical conductivity was estimated using current–voltage curves. The mechanical properties of the samples were evaluated using dynamic mechanical analysis (DMA) and correlated with the structural parameters of the composites. The adsorption and swelling properties paralleled the change in the electrical and mechanical properties of the materials. In most cases, samples with higher content of chitosan exhibit higher adsorption and mechanical properties, and lower conductivity. Acid-doped samples showed much higher adsorption, swelling, and electrical conductivity than their undoped analogues.

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“…The reason for this phenomenon is likely the fact that an excess concentration of Ga (III) ions can cause increased chelation with the polymer matrix. As a result, metal uptake occurs near the surface since the metal ions do not penetrate into the inner part of the polymer network [ 29 ], which can lead to the observed nanoscaled roughness. However, the formation of (amorphous) nanoprecipitates (e.g., Ga-hydroxides) cannot be ruled out as these would not be detectable by the applied techniques (SEM, XRD) and should be investigated in the future.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial

et al. 2021

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Even though antibiotic treatment remains one of the most common tools to handle bacterial infections, the excessive antibiotic concentration at the target site may lead to undesired effects. Aiming at the fabrication of antibiotic-free biomaterials for antibacterial applications, in this work, we propose the synthesis of gallium (III)—chitosan (Ga (III)-CS) complexes with six different gallium concentrations via an in situ precipitation method. Fourier Transform infrared spectroscopy indicated the chelation of chitosan with Ga (III) by peak shifts and changes in the relative absorbance of key spectral bands, while energy-dispersive X-ray spectroscopy indicated the homogenous distribution of the metal ions within the polymer matrix. Additionally, similar to CS, all Ga (III)-CS complexes showed hydrophobic behavior during static contact-angle measurements. The antibacterial property of the complexes against both Gram-negative and Gram-positive bacteria was positively correlated with the Ga (III) concentration. Moreover, cell studies confirmed the nontoxic behavior of the complexes against the human osteosarcoma cell line (MG-63 cells) and mouse embryonic fibroblasts cell line (MEFs). Based on the results of this study, new antibiotic-free antibacterial biomaterials based on Ga (III)-CS can be developed, expanding the scope of CS applications in the biomedical field.

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Synthesis, Characterization, Swelling, and Metal Uptake Studies of Aryl Cross-Linked Chitosan Hydrogels

Cited by 49 publications

References 50 publications

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Preparation of Multicomponent Biocomposites and Characterization of Their Physicochemical and Mechanical Properties

Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial

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