Synthesis, characterization, structural studies, DNA interaction, and cytotoxic studies of palladium(II) mixed-ligand complexes containing 2,2′-bipyridine, 5,6-dimethyl-1,10-phenanthroline and tetrazole-5-thiol ligands

Diacetonitrile(2,2′-bipyridine-κ2 N,N′)palladium(II) bis(trifluoromethanesulfonate)

“…Palladium(II) complexes of 2,2 0 -bipyridine continue to be investigated due to their application in catalysis (Kitanosono et al, 2021) and remarkable antiproliferative activity against cancer cells (Fatahian-Nezhad et al, 2021;Tabrizi et al, 2020;Icsel et al, 2015). Our research group has been exploring the synthesis of palladium(II) and copper(II) complexes containing various ancillary ligands.…”

Facile formation of tetrazole–thiolato Pd(ii) and Pt(ii) complexes through deprotonation or oxidative addition using organic tetrazole–thiones

“…The formation of transition-metal tetrazole-thiolato compounds from organic tetrazole-thiones has received continuous research attention owing to the structural or coordinative behavior of transition metals, which includes N-, S-, and N,Scoordination to the tetrazole-thiolato moiety (as shown in I-IV in Chart 1), 1,2 their abilities to inhibit metal corrosion, [3][4][5] and antibacterial (or anticancer) activities, [6][7][8] and theoretical studies. 6,9 Studies reported by several researchers have shown that N-(or S-) coordinated tetrazole-thiolates are formed through dipolar cycloaddition reactions of main-group or transitionmetal azido complexes with unsaturated organic compounds, such as R-NCS, R-SCN, and CS 2 .…”

“…18,19 Some late transition-metal tetrazole-thiolates have been synthesized by the deprotonation of organic tetrazole-thiones in the presence of amines, NaOH, or metal acetates. 2,[6][7][8][20][21][22][23][24][25] We previously reported that group-10 transition-metal azides react with organic isothiocyanates (R-NCS) or isocyanides (CN-R) through dipolar cycloaddition to afford the corresponding S-coordinated (or S,N-coordinated) or C-coordinated tetrazolato complexes (Scheme 1). 26 Although the synthesis of many late-transition metal tetrazole-thiolato compounds has been reported so far, studies on their chemical properties are very limited except several biomedical [6][7][8] or corrosive research studies.…”

“…2,[6][7][8][20][21][22][23][24][25] We previously reported that group-10 transition-metal azides react with organic isothiocyanates (R-NCS) or isocyanides (CN-R) through dipolar cycloaddition to afford the corresponding S-coordinated (or S,N-coordinated) or C-coordinated tetrazolato complexes (Scheme 1). 26 Although the synthesis of many late-transition metal tetrazole-thiolato compounds has been reported so far, studies on their chemical properties are very limited except several biomedical [6][7][8] or corrosive research studies. [3][4][5] As an independent route to the dipolar-cycloaddition reaction involving late transition-metal azides and unsaturated organic compounds shown in Scheme 1, in this study we attempted to synthesize tetrazole-thiolato complexes via direct deprotonation or oxidative addition using organic tetrazolethiones {SQ[CN 4 H(R)](R = alkyl, aryl)} and dialkyl Pd(II) or Pt(II) complexes and their zerovalent equivalents.…”

“…Compared to previous methods shown in Scheme 1, our methods presented here are expected to provide facile, convenient, and selective routes to various Pd(II) or Pt(II) tetrazolethiolates. We further examined small-molecule insertion reactions using an organic isocyanide as well as reactions involving electrophiles, which led to the isolation of new Pd(II) tetrazoletetrazole-thiolato complexes such as trans-[PdS{CN 4 (R)} 2 (PR 3 ) 2 ] (R = Ph, Me, allyl, i-Pr, indanyl; PMe 3 , PEt 3 ) 26a,f Pd-S = 2.33-2.40 Å, trans-[PdS{CN 4 (R)} 2 (PTA) 2 ] 16 (R = Ph, Et, allyl) Pd-S = 2.33-2.34 Å, cis-[Pd{SCN 4 (R)} 2 (L-L)](R = Ph, Me, Et, allyl) L-L = dppe, dppp, 6 Pd-S = 2.36-2.40 Å; L-L = bpy, dmphen, 8 Pd-S = 2.29-2.30 Å), and anionic [PdS{CN 4 (Me) 4 } 2À (Pd-S = 2.33-2.34 Å). 27 The bond length in complex 4 located in the trans position of the ethyl group is slightly longer than those of other tetrazole-thiolates, indicating a weaker trans influence of the ethyl group.…”