Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone

Abstract

Novel acyl pyrazolone and thio-Schiff base of acyl pyrazolone ligand HL (2-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene) hydrazine-1-carbothioamide) has been synthesised and characterized by FT-IR and 1H NMR techniques. This unusual coordinated complex [Zn(L)(CH3C00)(H2O)]CH3CH2OH has been synthesized and characterized by FT-IR, thermogravimetric analysis (TGA), UV-Vis spectroscopy and single crystal X-ray diffraction. 1H NMR confirms the structure of the thio-Schiff base used in the study. The structural data reveal that mononuclear Zn(II)complex has distorted square pyramidal geometry. S-S interaction, Inter molecular and intra molecular H-Bond found in crystal packing of the complex. The complex has been screened for MTT assay against A549 cell lines. The Zn(II) complex is cytotoxic against the screened cell line at low concentration.

A new multifunctional copper iodide–pyrazine hybrid for sensitive creatinine detection in biological samples: synthesis, structural features, characterization, and electrochemical evaluation

“…[6][7][8] This combination leads to unique coordination frameworks with diverse applications, including gas storage and separation, magnetism, optical technologies, etc. [9][10][11][12] The core appeal of metal-organic frameworks (MOFs) lies in their remarkable crystal engineering, which enables the formation of diverse extended framework structures. 13 These outstanding architectures are constructed by linking tetrahedral or octahedral metal cation centers with ligands and anion systems whose roles such as coordination arrangement, functional properties, steric and electronic effects, size, and ligand-binding ability collectively determine the topology (dimensionality) of the structures formed.…”

A new multifunctional copper iodide–pyrazine hybrid for sensitive creatinine detection in biological samples: synthesis, structural features, characterization, and electrochemical evaluation

“…[6][7][8] This combination leads to unique coordination frameworks with diverse applications, including gas storage and separation, magnetism, optical technologies, etc. [9][10][11][12] The core appeal of metal-organic frameworks (MOFs) lies in their remarkable crystal engineering, which enables the formation of diverse extended framework structures. 13 These outstanding architectures are constructed by linking tetrahedral or octahedral metal cation centers with ligands and anion systems whose roles such as coordination arrangement, functional properties, steric and electronic effects, size, and ligand-binding ability collectively determine the topology (dimensionality) of the structures formed.…”

Synthesis, spectral investigation, biological efficacy, and computational evaluation of the hydroxamic acid chelator and its Zn(II) metal complex with potent anticancer activity

“…Zinc is of paramount importance as a trace element for human physiology, contributing to cellular health, and participating in the activity of more than 300 enzymes [23,24]. Different classes of zinc coordination complexes have shown potential in various applications, including radioprotective agents [25], tumor photosensitizers [26], antidiabetic agents [27,28], anticonvulsants [29], antiinflammatory agents [30], antimicrobial agents [31][32][33][34][35][36][37][38], antioxidants [39], antiproliferative/antitumor agents [40,41] and anti-Alzheimer agents [42].…”

A new multifunctional copper iodide–pyrazine hybrid for sensitive creatinine detection in biological samples: synthesis, structural features, characterization, and electrochemical evaluation

“…[6][7][8] This combination leads to unique coordination frameworks with diverse applications, including gas storage and separation, magnetism, optical technologies, etc. [9][10][11][12] The core appeal of metal-organic frameworks (MOFs) lies in their remarkable crystal engineering, which enables the formation of diverse extended framework structures. 13 These outstanding architectures are constructed by linking tetrahedral or octahedral metal cation centers with ligands and anion systems whose roles such as coordination arrangement, functional properties, steric and electronic effects, size, and ligand-binding ability collectively determine the topology (dimensionality) of the structures formed.…”

Synthesis, spectral investigation, biological efficacy, and computational evaluation of the hydroxamic acid chelator and its Zn(II) metal complex with potent anticancer activity

“…Zinc is of paramount importance as a trace element for human physiology, contributing to cellular health, and participating in the activity of more than 300 enzymes [23,24]. Different classes of zinc coordination complexes have shown potential in various applications, including radioprotective agents [25], tumor photosensitizers [26], antidiabetic agents [27,28], anticonvulsants [29], antiinflammatory agents [30], antimicrobial agents [31][32][33][34][35][36][37][38], antioxidants [39], antiproliferative/antitumor agents [40,41] and anti-Alzheimer agents [42].…”

A new multifunctional copper iodide–pyrazine hybrid for sensitive creatinine detection in biological samples: synthesis, structural features, characterization, and electrochemical evaluation

“…[6][7][8] This combination leads to unique coordination frameworks with diverse applications, including gas storage and separation, magnetism, optical technologies, etc. [9][10][11][12] The core appeal of metal-organic frameworks (MOFs) lies in their remarkable crystal engineering, which enables the formation of diverse extended framework structures. 13 These outstanding architectures are constructed by linking tetrahedral or octahedral metal cation centers with ligands and anion systems whose roles such as coordination arrangement, functional properties, steric and electronic effects, size, and ligand-binding ability collectively determine the topology (dimensionality) of the structures formed.…”

Synthesis, spectral investigation, biological efficacy, and computational evaluation of the hydroxamic acid chelator and its Zn(II) metal complex with potent anticancer activity

“…Zinc is of paramount importance as a trace element for human physiology, contributing to cellular health, and participating in the activity of more than 300 enzymes [23,24]. Different classes of zinc coordination complexes have shown potential in various applications, including radioprotective agents [25], tumor photosensitizers [26], antidiabetic agents [27,28], anticonvulsants [29], antiinflammatory agents [30], antimicrobial agents [31][32][33][34][35][36][37][38], antioxidants [39], antiproliferative/antitumor agents [40,41] and anti-Alzheimer agents [42].…”