Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents

Triazine–benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors

“…The synthesis of triazine-benzimidazole hybrids and their substitution with primary and secondary amines as well as Suzuki couplings (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) has been depicted in Schemes 1-3. The aminobenzimidazoles 4a and 4b were prepared by benzylation of 2-methyl-5-nitro-1H-benzimidazole (2) with benzyl chloride in the presence of potassium carbonate at 80°C to give mixture of 3a and 3b followed by reduction with stannous chloride in 2 N HCl at 110°C (Scheme 1).…”

Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

“…11,23,[33][34][35][36][37][38] In this study, even though these benzimidazole analogues showed moderate antiproliferative activity, their unexpected selectivity towards MDA-MB-231 is interesting and worth pursuing further. To date, such selectivity remains uncommon for benzimidazole derivatives.…”

New approaches for the synthesis, cytotoxicity and toxicity of heterocyclic compounds derived from 2-cyanomethyl benzo[c]imidazole

“…1). 26,27 As the extension of this work, head to head bisbenzimidazole compounds proved high efficacy as DNA binders. 28 Some widely used anticancer drugs such as RAF265 (CHIR-265; Novartis Pharmaceuticals, Basel, Switzerland) and AZD6244 (ARRY-142886; AstraZeneca, London, England) are known to contain benzimidazole moiety.…”