Synthesis, characterization of Ru(III) macrocyclic complex with hirshfeld analysis and drug likeness study

Kanaoujiya, Rahul; Sahu, Dharmendra Kumar; Shankar, Vijay; Garima, .; Srivastava, Shekhar

doi:10.1016/j.matpr.2022.04.303

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…An octahedral geometry of the complex had been reported on the basis of above mentioned studies. The hirshfeld analysis was performed for the determination of three dimensional and two dimensional intermolecular interactions of surfaces of the ligand & crystal [ 36 ]. Based on drug likeness studies they disclosed that cyclam ligand could be used for enlargement of different type of drugs.…”

Section: Introductionmentioning

confidence: 99%

Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Bugalia,

Dhayal,

Sachdeva

et al. 2023

J Inorg Organomet Polym

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Role of synthetic coordination chemistry in pharmaceutical science is expeditiously increased due to its sundry relevances in this field. The present review endows the synthesized macrocyclic complexes of transition metal ions containing isatin and its derivatives as ligand precursors, their characterization and their copious pharmaceutical applications. Isatin (1 H -Indole-2,3-dione) is a protean compound (presence of lactam and keto moiety permits to change its molecular framework) that can be obtained from marine animals, plants, and is also found in mammalian tissues and in human fluids as a metabolite of amino acids. It can be used for the synthesis of miscellaneous organic and inorganic complexes and for designing of drugs since it has remarkable utility in pharmaceutical industry due to its wide range of biological and pharmacological activities, for instance anti-microbial, anti-HIV, anti-tubercular, anti-cancer, anti-viral, anti-oxidant, anti-inflammatory, anti-angiogenic, analgesic activity, anti-Parkinson’s disease, anti-convulsant etc. This review provides extensive information about the latest methods for the synthesis of isatin or its substituted derivatives based macrocyclic complexes of transition metals and their plentiful applications in medicinal chemistry. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Bugalia,

Dhayal,

Sachdeva

et al. 2023

J Inorg Organomet Polym

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“…Rosenberg's 1965 discovery of cis‐diamine dichloroplatinum (II), i. e. cisplatin, [1] and its successors are among the most efficacious chemotherapeutic drugs now in clinical usage (Figure 1), and are commonly considered as first‐line treatment for testicular, [2] and ovarian [3] tumours. They are, nevertheless, not without flaws.…”

Section: Introductionmentioning

confidence: 99%

Ruthenium Complexes as Potential Cancer Cell Growth Inhibitors for Targeted Chemotherapy

Katheria

2022

ChemistrySelect

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The effective clinical use of the three generation platinum anticancer drugs, cisplatin, carboplatin, and oxaliplatin, has sparked interest in metallodrugs; however, drug resistance and side effects have hampered their continued use and effects. Ruthenium(III) complexes have been successfully used in clinical research, and their anticancer mechanisms have been extensively reported during the last few decades. Ruthenium(II) complexes have also received a lot of attention as anticancer alternatives, but only a few of them have been thoroughly investigated. The development of ruthenium compounds as target‐specific chemotherapeutic drugs has received a lot of attention in recent years. Indeed, a few reviews summarising the research on cancer targeting ruthenium complexes have been published previously. We looked at studies on the target specific mechanism of action of ruthenium complexes for numerous organelles endoplasmic reticulum, nucleus, mitochondria,), DNA, intracellular proteins, and certain enzymes (carbonic anhydrase, TopoisomeraseI), all of which are upregulated in cancer cells and provide a specific mechanism for cancer cell death. This review will provide readers with a general overview of the different ruthenium complexes available for targeted chemotherapy, as well as information to aid in the design and creation of new anticancer ruthenium complexes research.

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Performance evaluation of all-inorganic cesium-based perovskite solar cell with BaSnO3 as ETL

Tara,

Bharti,

Dixit

et al. 2023

J Nanopart Res

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Synthesis, characterization of Ru(III) macrocyclic complex with hirshfeld analysis and drug likeness study

Cited by 5 publications

References 27 publications

Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Ruthenium Complexes as Potential Cancer Cell Growth Inhibitors for Targeted Chemotherapy

Performance evaluation of all-inorganic cesium-based perovskite solar cell with BaSnO3 as ETL

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