Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol esterase agents

Şahin, Ömer; Özdemir, Uğur; Seferoğlu, Nurgül; Adem, Şevki; Seferoğlu, Zeynel

doi:10.1080/07391102.2020.1858163

Cited by 15 publications

(7 citation statements)

References 37 publications

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“…Sahin and coworkers synthesized a Schiff base-coumarin hybrid and coordinated it with Pd(II) or Pt (II) (compound 65) ( Şahin et al, 2022 ). The novel compounds were tested for inhibitory activity toward AChE, butyrylcholinesterase (BChE), and pancreatic cholesterol esterase (CEase).…”

Section: Coumarin Complexes As Enzyme Inhibitors and Antihaemolytic A...mentioning

confidence: 99%

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Todorov,

Kostova

2024

Front. Chem.

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Coumarin (2H-1-benzopyran-2-one) presents the fundamental structure of an enormous class of biologically active compounds of natural, semi-synthetic, and synthetic origin. Extensive efforts are continually being put into the research and development of coumarin derivatives with medicinal properties by the broad scientific community. Transition metal coordination compounds with potential biological activity are a “hot topic” in the modern search for novel drugs. Complexation with transition metals can enhance the physiological effect of a molecule, modify its safety profile, and even imbue it with novel attributes of interest in the fields of medicine and pharmacy. The present review aims to inform the reader of the latest developments in the search for coumarin transition metal complexes with biological activity, their potential applications, and structure-activity relationships, where such can be elucidated. Each section of the present review addresses a certain kind of biological activity (antiproliferative, antioxidant, antimicrobial, etc.), explores the most recent discoveries in the field, and, at the same time, tries to offer useful perspectives for potential future investigations.

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Section: Coumarin Complexes As Enzyme Inhibitors and Antihaemolytic A...mentioning

confidence: 99%

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Todorov,

Kostova

2024

Front. Chem.

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“…The 100 ml of pure water, the 80 μL of 100 mM Tris-SO4 buffer (pH: 8.0), the 80 μl of 3 mM 4-nitrophenyl acetate, and 20 μL enzyme were added to the reaction mix for human CA isoenzymes (hCAI and hCAII). [27] For porcine PCE activity assay, the reaction mixture was created by adding 80 μl of 100 mM phosphate buffer (pH:7) containing 100 mM NaCl, 100 μl of 12 mM NAT, 20 μl of 20 mM p-nitrophenyl butyrate at assay buffer, 80 μL of pure water and 10 μL enzyme [28,29] For inhibition studies, the compound was dissolved as 1 mg/ml at DMSO, and then diluted 10 times with distilled water to use as a stock solution. Enzyme activities were assayed at the different inhibitory concentrations by reducing the amount of water as much as the inhibitor volume.…”

Section: Enzyme Studiesmentioning

confidence: 99%

Biological Effects and Crystal X‐Ray Study of Novel Schiff Base Containing Pentafluorophenyl Hydrazine: In Vitro and in Silico Studies

Hamurcu,

Özmen,

Şentürk

et al. 2023

Chemistry & Biodiversity

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A novel Schiff base namely 3,5‐di‐tert‐butyl‐6‐((2‐(perfluorophenyl) hydrazono) methyl) phenol was successfully synthesized and characterized using FTIR and 1H‐NMR, 13C‐NMR, and 19F‐NMR. The crystal structure analysis of the Schiff base compound was also characterized with single crystal X‐ray diffraction studies and supported the spectroscopic results. The cytotoxicity, anti‐bacterial properties, and enzyme inhibition of the compound were also investigated. The molecular docking studies were performed in order to explain the interactions of the synthesized compound with target enzymes. The newly synthesized hydrazone derivative Schiff base compound showed high cellular toxicity on MCF‐7 and PC‐3 cells. Also, this compound caused low antibacterial effect on E. coli and S. aureus. Besides, the compound exhibited the inhibitory effect against pancreatic cholesterol esterase and carbonic anhydrase isoenzyme I, II with IC50 values 63, 99, and 188 µM, respectively. Consequently, it has been determined that the prepared Schiff base is an active compound in terms of cytotoxicity, enzyme inhibition, and anti‐bacterial properties. These results provide preliminary information for some biological features of the compound and can play a major role in drug applications of the Schiff base compound.

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“…Şahin et al demonstrated the inhibitory potency of palladium (II) and platinum (II) complexes of coumarin-based ligand - 3-{2-[(3-( tert -butyl)-2-hydroxybenzylidene)amino]thiazol-4-yl}-2 H -chromen-2-one 54 and 55 ( Table 1 ) against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and pancreatic cholesterol esterase (cease) ( Şahin et al, 2020 ). The inhibitory properties against AChE, BChE, and cease of synthesized complexes were determined by a standard procedure involving the spectrophotometric measurements according to Elman or Pietsch and Gütschow methods.…”

Section: Enzyme Inhibiting Complexesmentioning

confidence: 99%

A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties

et al. 2021

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The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. On the other hand, it has been reported that the incorporation of a metal ion into coumarin derivatives can increase the activity of such complexes compared to coumarin-based ligands. Accordingly, some of them have been found to display promising antioxidant, antitumor or antibacterial activities. This mini-review briefly summarizes the recent development of coumarin-metal complexes with proven biological properties. The attention is also paid to agents for which practical applications in the detection of biologically important species may be found.

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Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol esterase agents

Cited by 15 publications

References 37 publications

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Biological Effects and Crystal X‐Ray Study of Novel Schiff Base Containing Pentafluorophenyl Hydrazine: In Vitro and in Silico Studies

A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties

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