Synthesis, Characterization, Molecular Docking, Acetylcholinesterase and α‐Glycosidase Inhibition Profiles of Nitrogen‐Based Novel Heterocyclic Compounds

Abstract

In this study, a series of nitrogen-based novel heterocyclic compounds were synthesized and characterized by elemental analysis, IR and NMR spectra. The novel synthesized nitrogenbased novel heterocyclic compounds were evaluated against the acetylcholinesterase (AChE) and α-glycosidase enzymes. These compounds showed IC 50 values in range of 0.76-28.04 μM against AChE as a cholinergic enzyme, and 26.10-82.17 μM against α-glycosidase as a hydrolytic enzyme. On the other hand, they demonstrated K i values between 1.25 � 0.22-25.36 � 4.72 μM against AChE, and 25.07 � 4.57-78.55 � 17.04 μM against α-glycosidase enzymes. The synthesized nitrogen-based novel heterocyclic compounds exhibited effective inhibition profiles against both indicated metabolic enzymes. These results may contribute to the development of new drugs particularly to treat some disorders, which widespread display in the world including Alzheimer's disease and diabetes. Furthermore, molecular docking calculations were made to compare the theoretical biological activities of nitrogen-based novel heterocyclic compounds against proteins including enzymes. After these calculations, ADME/T analysis was performed to examine the drug properties of nitrogenbased novel heterocyclic compounds.

Novel Benzoic Acid Derivatives Bearing Quinazolin‐4(3H)‐one Ring: Synthesis, Characterization, and Inhibition Effects on α‐Glucosidase and α‐Amylase

“…Inhibition values of the compounds were evaluated against Acarbose, the standard inhibitor for both enzymes. Inhibition values of the novel compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) for the α-Glucosidase and α-Amylase were presented in Table 1…”

“…Additionally, αamylases are enzymes that catalyze the hydrolysis of α-1,4glycosidic bonds in starch molecules. [2][3][4] They can be obtained from various sources. Although found in all living organisms, activity, specificity, and necessity vary from species to species and even from tissue to tissue.…”

Synthesis and Biological Activity of Functionally Substituted Pyrimidine and Pyran Derivatives on the Basis of Isatylidene Malononitriles

“…Alzheimer's disease (AD) is a degenerative and progressive brain disorder that first influences older people and reduces the ability to perform regular actions and leads to memory loss. AD is the foremost reason for dementia, influencing about 50 million persons worldwide, plus about 10 million new patients per year [6–8] . AD contributes 60–70 % of dementia patients.…”

“…AD is the foremost reason for dementia, influencing about 50 million persons worldwide, plus about 10 million new patients per year. [6][7][8] AD contributes 60-70 % of dementia patients. Indeed, the actual character or reason of AD stays uncertain, and for this reason, the improvement of an efficient anti-Alzheimer's is one of the profitable areas of the current study in medicinal chemistry.…”

Synthesis of Functional Polyesters N-(2,3-epoxypropyl)-4,5,6,7-tetrahydroindole by Anionic Ring-Opening Polymerization

“…The improvement of the synthesis method of 4,5,6,7-tetrahydroindole [ 21 , 22 , 23 ], which makes it possible to obtain inexpensive THI on an industrial scale, accelerated the process of practical use of 4,5,6,7-tetrahydroindole derivatives. Thus, the prospects of using THI derivatives in the synthesis of drugs for the treatment of diseases such as Alzheimer’s disease and diabetes mellitus are shown [ 24 ]. THI derivatives are also promising in the treatment of oncological [ 25 , 26 ], viral [ 26 ], neurodegenerative diseases [ 27 ].…”