Synthesis, characterization, electrochemical and biological activities of mixed ligand copper(II) complexes with dimethylglyoxime and amino acids

Bougherra, Hadda; Berradj, Omar; Adkhis, A.; Amrouche, Tahar

doi:10.1016/j.molstruc.2018.06.088

Cited by 28 publications

(16 citation statements)

References 47 publications

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“…The complex 5 was synthesized by a procedure similar to that for 4 and therefore a similar complex was expected but containing guaninate instead of adeninate. The IR spectrum of 5 showed the typical bands for coordinated guaninate (δ(NH 2 )=1672 (s); ν(C=O)=1608 (s); ν(C=C+C=N)=1564 (m)), and its 1 H NMR spectrum displays the characteristic signals for PPh 3 , PTA and Cp in a piano‐stool configuration . The guaninate signals arise at 5.86 ppm (NH 2 ) and 7.14 ppm (C8‐H), which are similar to those found for 2 (δ(C8‐H) = 7.35 ppm).…”

Section: Resultssupporting

confidence: 60%

CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties

et al. 2019

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Complexes [RuCp(Adeninate‐κN9)(PTA)2] (1), [RuCp(Guaninate‐κN9)(PTA)2] (2), [RuCp(Theophyllinate‐κN7)(PTA)2] (3), [RuCp(Adeninate‐κN9)(PPh3)(PTA)] (4), [RuCp(Guaninate‐κN9)(PPh3)(PTA)] (5) and [RuCp(Theophyllinate‐κN7)(PPh3)(PTA)] (6) were synthesized and characterized by NMR spectroscopy, elemental analysis and FT‐IR (PTA = 1,3,5‐triaza‐7‐phosphaadamantane). Crystal structures of 1·H2O·3EtOH, 3·CH3COCH3 and 4·H2O were also determined by single‐crystal X‐ray diffraction. The antiproliferative activities of the complexes against cisplatin‐sensitive T2 and cisplatin‐resistant SKOV3 cell lines have also been evaluated. Theoretical studies were preformed to elucidate how the adeninate ligand is coordinated to the metal.

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Section: Resultssupporting

confidence: 60%

CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties

et al. 2019

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“…The reduced form of the Schiff base, derived from an amino acid and a carbonyl compound (e.g., salicylaldehyde), can form transition metal complexes with important applications [ 4 , 5 , 6 ]. Amino acids play important roles in various biochemical processes as endogenous ligands; in addition, their complexes with biologically-active metal ions have also proved to be useful antibacterial agents and metalloprotein models [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

et al. 2020

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The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.

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“…Fluorescent Behavior: Photochromism defines that in the presence of light, the molecules exhibit different absorption spectra with different colors [27][28][29][30][31][32] . This phenomenon attributes different sensing applications [33][34][35][36] .…”

Section: Absorption Spectral Titrationsmentioning

confidence: 99%

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2020

IJPSR

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Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization within the molecule and leads to longer wavelength. INTRODUCTION: Metal-containing compounds/ complexes offer many distinct advantages over traditional organic i.e., carbon-based compounds in the development of new medicinal lead molecules due to their capability to coordinate ligands/organic molecules 1-6 .

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Synthesis, characterization, electrochemical and biological activities of mixed ligand copper(II) complexes with dimethylglyoxime and amino acids

Cited by 28 publications

References 47 publications

CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties

CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

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