Synthesis, characterization, duplex‐DNA interactions, and anticancer activities of novel octahedral [Ni(phen)2(dppz‐idzo)]2+ and [Co(phen)2(dppz‐idzo)]3+ complexes

Abulhasanov, Bahrouz; Yıldız, Ufuk; Akkoç, Senem; Çoban, Burak

doi:10.1002/aoc.5866

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…With the addition of DNA to this complex solution, strong (18 %) hypochromism was observed. The intrinsic binding constant value K b for 2 was calculated [26,27,31,58,104] based on the peak at 272 nm as 2.50 × 10 5 M À 1 .…”

Section: Spectrophotometric Studies On Dna Interactions Of the Ligands And Complexesmentioning

confidence: 99%

“…An anknown complex, which is involved in a strong DNA intercalation, would compete with the intercalatively bound EB for DNA binding and quench the EtBr emission. [26,27,58,104] The same rule works for the DNA groove binder Hoechst-33258. [116] The results can be interpreted by classical Stern-Volmer equation to calculate the binding degree of the compounds.…”

Section: Compoundsmentioning

confidence: 99%

“…In the 1 H-NMR spectrum, dbfip displays two singlets at 9.05 ppm and 8.30 ppm due to 6 protons in phenanthroline ring and the rest of the peaks standard of 2substituted dibenzofuran ring. The 13 C-NMR spectrum of dbfip To make the nickel complexes, an ethanolic solution of a previously synthesized nickel complex [104,105] [Ni(phen) 2 (H 2 O)Cl] Cl was heated to reflux in the presence of the ligand (btdip or dbfip). [Ni(phen) 2 (btdip)](ClO 4 ) 2 complex (1) was isolated as yellow powder after addition of an excess of NaClO 4 in a concentrated solution of the reacting mixture.…”

Section: Synthesis Of the Ligands And Complexesmentioning

confidence: 99%

“…With the addition of DNA a strong (18 %) hypochromism at 267 nm and a small hypochromism at 408 nm with 1 nm red shift were observed. The intrinsic binding constant value K b for 1 was calculated [26,27,31,58,104] based on the peak at 267 nm as 6.4 × 10 5 M À 1 . The absorption spectrum of the [Ni(phen) 2 (dbfip)] 2 + complex (2) (Figure 4d), on the other hand, gives an absorption maximum at 272 nm.…”

Section: Spectrophotometric Studies On Dna Interactions Of the Ligands And Complexesmentioning

confidence: 99%

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DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

et al. 2021

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Two new imidazophenanthroline derivatives, namely 2-(4bromo-(2,1,3)-benzothiadiazol-7-yl)-1H-imidazo [4,5- [1,10]phenanthroline (dbfip) and their octahedral nickel complexes [Ni(phen) 2 (btdip)] 2 + (1) and [Ni(phen) 2 (dbfip)] 2 + (2) have been synthesized and characterized by CHN analysis, ESI-MS, NMR and UV-vis spectra. Their DNA binding abilities were spectrophotometrically, hydrodynamically and electrophoretically studied and found that while btdip binds DNA externally, dbfip binds in the grooves and both of their nickel complexes also bind DNA through grooves giving severe DNA damage in the presence of peroxide. The compounds were screened against four different human cancer cell lines using MTT assay method. The results obtained showed that both ligands are active against DLD-1, and further dbfip is found to be more active than positive control drugs against DLD-1 and HepG2 cell lines. The complex 2 has more antiproliferative effect than 1 against MCF-7 and HepG2 cells. On the other hand, complex 2 was found to have more toxic effect on HepG2 cells than the standard drugs cisplatin and ploxal-S.

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Section: Spectrophotometric Studies On Dna Interactions Of the Ligands And Complexesmentioning

confidence: 99%

Section: Compoundsmentioning

confidence: 99%

Section: Synthesis Of the Ligands And Complexesmentioning

confidence: 99%

Section: Spectrophotometric Studies On Dna Interactions Of the Ligands And Complexesmentioning

confidence: 99%

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DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

et al. 2021

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“…Schiff base ligands having triazole ring can be considered as "privileged structures" and are widely used due to their novel structural features. Transition metal complexes have effectively established them as good antimicrobial and anticancer agents [31,32]. Therefore, the formation of transition metal chelates of triazole derived Schiff base ligands as new metallodrugs for the treatment of various diseases is found to have great potential.…”

Section: Introductionmentioning

confidence: 99%

Transition metal complexes of triazole-based bioactive ligands: synthesis, spectral characterization, antimicrobial, anticancer and molecular docking studies

et al. 2021

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In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones

Mathews

Kurup

2020

Applied Organom Chemis

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Among all the bio-metals, zinc and copper derivatives of ONS donor thiosemicarbazone have aroused great interest because of their potential biological applications. Multisubstituted thiosemicarbazone ligand H 2 dspt (3,5-dichlorosalicylaldehyde-N 4-phenylthiosemicarbazone) derived new ternary complexes like [Zn(dspt)(phen)]‧DMF (1) and [Cu(dspt)(phen)]‧DMF (2), and another thiosemicarbazone, H 2 dsct (3,5-dichlorosalicylaldehyde-N 4cyclohexylthiosemicarbazone), derived [Cu(dsct)(bipy)]‧DMF (3). These complexes have been characterized by elemental analysis (CHNS), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) and proton nuclear magnetic resonance (1 H-NMR) spectra. The structures of the complexes were obtained by single-crystal X-ray diffraction analysis. Compounds 1 and 2 got crystallized in the monoclinic P2 1 /c space group. The complexes showed interesting supramolecular interaction, which in turn stabilizes the complexes. The ground state electronic configurations of the complexes were studied using the B3LYP/LANL2DZ basis set, and ESP plots of complexes were investigated. The interaction of the complexes with calf thymus DNA (CT-DNA) was studied using absorption and fluorescence spectroscopic methods. A UV study of the interaction of the complexes with calf thymus DNA (CT-DNA) has shown that the complexes can effectively bind to CT-DNA, and [Cu(dspt)(phen)]Á DMF (2) exhibited the highest binding constant to CT-DNA (K b = 3.7 × 10 4). Fluorescence spectral studies also indicated that Complex 2 binds relatively stronger with CT DNA through intercalative mode, exhibiting higher binding constant (K q = 4.7 × 10 5). The DNA cleavage result showed that the complexes are capable of cleaving the DNA without the help of any external agent. Molecular docking studies were carried out to understand the binding of complexes with the molecular target DNA. Complex 2 exhibited the highest cytotoxicity against human breast cancer cell line MD-MBA-231 (IC 50 = 23.93 μg/mL) as compared to Complex 1 (IC 50 = 44.40 μg/mL).

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Synthesis, characterization, duplex‐DNA interactions, and anticancer activities of novel octahedral [Ni(phen)₂(dppz‐idzo)]²⁺ and [Co(phen)₂(dppz‐idzo)]³⁺ complexes

Cited by 7 publications

References 39 publications

DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

Transition metal complexes of triazole-based bioactive ligands: synthesis, spectral characterization, antimicrobial, anticancer and molecular docking studies

In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones

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