Synthesis, characterization, DNA interaction and cleavage activity of new mixed ligand copper(II) complexes with heterocyclic bases

Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide

“…The binding constant Kb for complex 2 was found to be 6.6 x 10 4 M -1 at 268 nm, with the hypochromicity of about 10.34 %. The extent of hypochromism and red-shift observed for the mixed ligand complexes 1 and 2 are better comparing with the literature work [41,42] and lower than those observed for typical classical intercalators such as ethidium bromide (Kb, 1.4 x 10 6 M -1 in 25 mM Tris-HCl/40 mM NaCl buffer, pH = 7.9) [43] bound to CT DNA.…”

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

“…On the other hand, the pBR322 DNA treated with the ligands (3)(4)(5)(6)(7)(8) are remarkably degrading the pBR322 DNA by oxidative (O 2 -dependent pathway) cleavage mechanism using the singlet oxygen as the reactive species [44,46]. These results are similar to that observed for some Cu(II) and Ni(II) complexes as chemical nuclease [47][48][49][50][51][52]. ) were determined by the picrate extraction method developed by Pedersen [53].…”

Metal-Based Biologically Active Agents: Synthesis, Characterization, Antimicrobial and Biochemical Studies of Mixed Ligand Complexes

“…It is evident that the complexes cleave DNA more effectively in the presence of oxidant. These hydroxyl radicals participate in the oxidation of the deoxyribose moiety, followed by the hydrolytic cleavage of the sugar-phosphate backbone (Babu et al, 2007).…”