Synthesis, Characterization, DNA Cleavage, and Antimicrobial Studies of Some Transition Metal Complexes With a Novel Schiff Base Derived From 2-Aminopyrimidine

Sindhu, Y.; Athira, C.J.; Sujamol, M.S.; Joseyphus, R. Selwin; Mohanan, K.

doi:10.1080/15533174.2012.740711

Cited by 20 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…is means that it is possible that these labile ligands may be displaced by the donor atoms found in the genomic material. is could lead to strong interactions that lead to complete damage of the genomic material [36][37][38]. is strong interaction completely disrupts the conformation of the DNA and the bonds that make up the DNA polymer where now the base pairs are no longer bound together.…”

Section: Gel Electrophoresis Assaymentioning

confidence: 99%

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

Matshwele

Nareetsile

Mapolelo

et al. 2020

Journal of Chemistry

View full text Add to dashboard Cite

The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species. The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility. Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complexes suggest that they are of a low spin crystal field split, where the Ru(III) is a d5 and Ru(II) d6 low spin. These compounds were tested for antibacterial activity on two bacterial species: Staphylococcus aureus (S. aureus) and Klebsiella pneumoniae (K. pneumoniae), as well as their drug-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) and multidrug resistant Klebsiella pneumoniae (MDR K. pneumoniae). All the compounds inhibited growth of the two non-drug-resistant bacteria and only one drug-resistant strain MRSA. However, only the ligands BUT and 2,2-dipyridylamine showed activity against MRSA, while all complexes did not show any antibacterial activity on MRSA. We observed large zones of inhibition for the Gram-positive S. aureus and MRSA bacteria, compared to the Gram-negative K. pneumoniae bacteria. DNA cleavage studies with gel electrophoresis showed denatured bacterial DNA on the gel from all the complexes, with the exception of the ligand, suggesting DNA nuclease activity of the complexes in the bacterial DNA.

show abstract

Section: Gel Electrophoresis Assaymentioning

confidence: 99%

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

Matshwele

Nareetsile

Mapolelo

et al. 2020

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…The efficiency of these compounds often enhanced upon coordination to a metal has been proven for the drug action acceleration of therapeutic agents [22][23][24][25][26] and for multi-compounds reaction where these complexes are used as intermediates. Recently, extensive research has surrounded the synthesis of lanthanide complexes and precisely the cerium (III) complexes using cerium (III) heptahydrate (CeCl 3 · 7 H 2 O) 27 .…”

Section: Introductionmentioning

confidence: 99%

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

Imanelakehal¹,

Farhihalamia²,

Saoussenlakehal³

et al. 2016

Orient. J. Chem

View full text Add to dashboard Cite

Complex of cerium (III) with (E)-N-benzylidene-4-methoxyaniline is synthesized through a one-pot three-component reaction from aromatic aldehyde, aromatic amine and the CeCl 3 · 7 H 2 O, as an efficient catalyst. This cerium (III) complex is characterized by IR, 1H, and 13C NMRspectroscopy and mass-spectral data. Molecular structure, Mullikan charges, thermodynamic parameters; vibrational frequencies and intensities were calculated by Density Functional theory methods (B3LYP, B3PW91, mPW1PW91 and PBEPBE) using the SDD basis set. The comparison between the calculated and experimental data in order to attain the best quality and to predict the structure, the best performance in the vibration spectra perfected of the title compound, we have found that the harmonic vibration computed are in a good agreement with the observed in IR spectrum, for closest match we calculated optimal scaling factors can recommend for the IR spectral future predictions for unknown compounds of this class. In order to better comparison, we also root mean square values of the experimental and calculated IR bands are 16.64, 16.64, 17.45, 17.66 and the mean absolute percentage error values are 1.33, 1.39, 1.40, and 1.5 for B3LYP, B3PW91, mPW1PW91, and PBEPBE methods respectively.

show abstract

“…e chain in the mononuclear complexes does not connect to anything. are assumed to be the contributing factors to the observed DNA denaturing activity [6,[21][22][23]. ese data suggest that DNA nuclease/denaturing may be the mode of action for the complexes, especially that they showed bactericidal concentrations.…”

Section: Dna Chelation Assaymentioning

confidence: 96%

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Matshwele

Odisitse

Mapolelo

et al. 2021

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

A new hexadentate 2-picolyl-polypyridyl-based ligand (4, 4'-(butane-1, 4-diylbis(oxy))bis(N, N-bis(pyridin-2-ylmethyl)aniline)) (2BUT) (1) and its corresponding Ru(II/III) complexes were synthesized and characterized, followed by assessment of their possible bioactive properties towards drug-resistant and non-drug-resistant bacteria. Spectroscopic characterization of the ligand was done using proton NMR, FTIR, and ESI-MS, which showed that the ligand was successfully synthesized. The Ru(II/III) complexes were characterized by FTIR, UV/Vis, elemental analysis, proton NMR, ESI-MS, and magnetic susceptibility studies. The analysis of ESI-MS data of the complexes showed that they were successfully synthesized. Empirical formulae derived from elemental analysis of the complexes also indicated successful synthesis and relative purity of the complexes. The important functional groups of the ligands could be observed after complexation using FTIR. Magnetic susceptibility data and electronic spectra indicated that both complexes adopt a low spin configuration. The disc diffusion assay was used to test the compounds for antibiotic activity on two bacteria species and their drug-resistant counterparts. The compounds displayed antibiotic activity towards the two non-drug-resistant bacteria. As for the drug-resistant organisms, only [Ru2(2BUT)(DMF)2(DPA)2](BH4)43 and 2, 2-dipyridylamine inhibited the growth of MRSA. Gel electrophoresis DNA cleavage studies showed that the ligands had no DNA cleaving properties while all the complexes denatured the bacterial DNA. Therefore, the complexes may have DNA nuclease activity towards the bacterial genomic material.

show abstract

Synthesis, Characterization, DNA Cleavage, and Antimicrobial Studies of Some Transition Metal Complexes With a Novel Schiff Base Derived From 2-Aminopyrimidine

Cited by 20 publications

References 38 publications

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Contact Info

Product

Resources

About