Synthesis, characterization, DNA-binding studies and acetylcholinesterase inhibition activity of new 3-formyl chromone derivatives

Studying non-covalent drug–DNA interactions

“…Viscosity measurement is a hydrodynamic method of determining the binding mode of drug with DNA [55][56][57]. It is highly sensitive to change in the length of DNA and is considered as one of the most reliable techniques for DNA binding studies in solution.…”

First Principles Study on the Stability and Electronic Structures of 7,8-Dichloro-4-Oxo-4H-Chromene-3-Carbaldehyde

“…In the case of Mulliken atomic charges, the computed charges of C 4 and C 6 atoms are about +0.284 and +0.238, which have the highest positively charges in the title compound using DFT/B3LYP/6-31G simulation approach. The charges of Cl 1 …”

“…3(b)), both atoms of C 4 and C 6 becomes more positive than B3LYP/6-31G calculation, respectively, with the corresponding values about +0.311 and +0.393. For the title molecule, the charges of Cl 1 …”

“…Many substituted 3-Formylchromone has been synthesized, and their properties have been studied [1][2][3][4][5][6]. There have been recently received considerable attentions as a subject to the academic researches.…”

Formation, electrochemical and radical scavenging properties of novel ruthenium compounds with N, X-donor (X=O, N) heterocyclic chelators

“…Particular interest to us, is the utilization of heterocyclic-derived ligands incorporating benz(imidazole/othiazole/oxazole) moieties due to their multitude of biological activities [3][4][5]. In addition, the secondary metabolite, chromone and its organic and inorganic compounds have proven to exhibit potent anticancer activities against a wide range of cancer cell lines [6][7][8][9]. Most recently, we have also designed Schiff bases containing the tetrahydro-2H-pyrane moiety which shares the same backbone structure as the sugar derivative, mannose.…”