Synthesis, characterization, DNA binding and catalytic applications of Ru(III) complexes

Shoair, A.F.; El-Shobaky, A.R.; Azab, E.A.

doi:10.1016/j.saa.2015.06.011

Cited by 16 publications

(6 citation statements)

References 53 publications

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“…On the other hand, hyperchromicity and hypsochromism (blue shift) are consistent with electrostatic interactions and non-intercalative binding mode. [42][43][44] In these experiments, we preferred to use H 2 O as a solvent due to distribution and bioavailability in the body. 19 The absorption spectra of compounds 2a, 3a and 4a in the absence and presence of CT-DNA were recorded ranging from 800 to 350 nm and can be observed in Fig.…”

Section: 2mentioning

confidence: 99%

The water soluble peripherally tetra-substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines as new potential anticancer agents

et al. 2016

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In this study, [2-(2-morpholin-4-ylethoxy)ethoxy] group substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines 2-4 and their water soluble derivatives 2a, 3a and 4a were synthesized and the interactions of compounds 2a, 3a and 4a with CT-DNA and supercoiled pBR322 plasmid DNA were investigated. The results of binding experiments showed that these compounds were able to interact with CT-DNA via intercalative mode with a strong binding affinity in the order 3a > 2a > 4a. DNA-photocleavage activities of compounds 2a, 3a and 4a were determined. These compounds cleaved supercoiled pBR322 plasmid DNA efficiently under irradiation at 650 nm for 2a and 4a, and at 750 nm for 3a. These compounds displayed remarkable inhibitory activities against topoisomerase I enzyme in a dose-dependent manner. All of these results suggest that these phthalocyanines might be suitable anticancer agents due to their strong binding affinities, significant cleavage activities and effective topoisomerase I inhibition.

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Section: 2mentioning

confidence: 99%

The water soluble peripherally tetra-substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines as new potential anticancer agents

et al. 2016

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“…The plates were incubated at 37 °C for 24 hours to determine the zones of inhibition of microbial growth induced by the various complexes (mm). All the tests were done three times [11][12][13][14].…”

Section: Antimicrobial Studiesmentioning

confidence: 99%

Synthesis, characterization, biological activity, molecular docking and thermal analysis of binuclear complexes

Abou‐Melha¹

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. Because of their potential medical applications as antimicrobial medicines, metal-ligand complexes have sparked a lot of attention. Synthesis and characterization of various metal-diamine complexes were the goals of the research detailed in this paper. As a result, synthesis of new binuclear ligand; N,N'-bis(3-carboxysalcylidene)-4-chloro-1,2-phenylenediamine (H4fsacph) which is derivative from the condensation of 3-formyl-2-hydroxybenzoic acid and 4-chlorobenzene-1,2-diamine has been performed. The new synthesized ligand has formed a mononuclear complex with Cu(II). The mononuclear Cu(II) complex was used to form binary nuclear complexes with some metal ions, like Cr(III), Mn(II), Fe(III), Ru(III), Pd(II) and La(III) ions. Elemental analysis, IR, UV-Visible, and thermal analyzes have been used to characterize the complexes. The interaction of a ligand with the receptors of Candida albicans and SARS-CoV-2 was predicted using molecular docking. Toward bacteria and fungi showing predominant activity against all fungi verified antibacterial activity of the synthesized complexes, while they have almost no activity against all bacteria. All compounds have shown antibacterial and antifungal activities, but the metal complexes showed better activities as compared to the original ligands, especially all zinc(II) complexes. The above results suggest that both ligands and their metal complexes have the potential to be explored as active pharmaceutical agents. KEY WORDS: Molecular structure, Metal complexes, Molecular docking, Antimicrobial, SARS-CoV-2, Antifungal Bull. Chem. Soc. Ethiop. 2022, 36(4), 843-858. DOI: https://dx.doi.org/10.4314/bcse.v36i4.10

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“…7 In the last decade a variety of ruthenium complexes, that provide great interest specially for their catalytic activity, has been developed. [8][9][10] Ruthenium metal complexes may be also relevant as therapeutic agents and one of these has successfully entered advanced clinical trials. 11 In fact the energy barrier for the oxidation state change from Ru(III) to Ru(II) inside the cell is very low and due to the larger coordination number with respect to platinum-(II), ruthenium-(III/II) can form complexes with a number of elements having different electronegativity as well as chemical hardness.…”

Section: Introductionmentioning

confidence: 99%

Catecholase-Like Activity and Theoretical Study in Solid State of a New Ru(III)-Schiff Base Complex

Biswas

Saha

Zangrando

et al. 2021

ACSi

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A new ruthenium(III) complex of molecular formula [Ru(PPh3)Cl2(L)] (1) has been synthesized using the Schiff base ligand obtained from 5-chlorosalicylaldehyde and N,N-dimethylethylenediamine and characterized by FT-IR, UV-Vis, cyclic voltammetry and single crystal X-ray structural analysis. The metal ion exhibits a slightly distorted octahedral environment where the chelating Schiff base ligand contributes with its NNO donor set. The coordination geometry around the Ru(III) ion is completed by a PPh3 ligand and two chloride anions, and the charge balance is assured by the phenoxo oxygen of the Schiff base. With the aim to analyse the energy related to the halogen bonding interactions in solid state, a theoretical study has been performed on complex 1, by using the MEP and NCl plot computational tools. Furthermore, complex 1 shows catecholase-like activity in conversion of the model substrate 3,5-di-tert-butylcatechol (3,5-DTBC) to the corresponding 3,5-di-tert-butylquinone (3,5-DTBQ) under aerobic condition. The parameters regarding the enzymatic kinetics have been evaluated from the Lineweaver-Burk plot using the Michaelis-Menten approach of enzyme catalysis. A significant high T.O.N value (2.346 × 103 h–1) indicates that complex 1 has a very good catalytic efficiency towards 3,5-DTBC.

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Synthesis, characterization, DNA binding and catalytic applications of Ru(III) complexes

Cited by 16 publications

References 53 publications

The water soluble peripherally tetra-substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines as new potential anticancer agents

The water soluble peripherally tetra-substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines as new potential anticancer agents

Synthesis, characterization, biological activity, molecular docking and thermal analysis of binuclear complexes

Catecholase-Like Activity and Theoretical Study in Solid State of a New Ru(III)-Schiff Base Complex

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