Synthesis, Characterization, Crystal Structure and Antibacterial Activities of Transition Metal(II) Complexes of the Schiff Base 2-[(4-Methylphenylimino)methyl]-6-methoxyphenol

Abstract

Five transition metal(II) complexes, [ML2Cl2] 1~5, were synthesized from the reaction of MCl2·nH2O (M = Mn, Co, Ni, Cu, Cd) and the Schiff base ligand 2-[(4-methylphenylimino)methyl]-6-methoxyphenol (C15H15NO2, L), obtained by condensation of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) with p-toluidine. They were characterized by elemental analysis, molar conductance, FT-IR spectra, thermal analysis. The structure of complex 1 was determined by single-crystal X-ray diffraction. Its crystal structure is of monoclinic system, space group P21/c with a = 9.0111(18) Å, b = 11.222(2) Å, c =28.130 (6) Å, α = 90 º, β = 92.29(3) º, γ = 90 º, V = 2867.6(10) Å3, Z = 4. The Mn atom is six-coordinate and displays distorted octahedral geometry. The Schiff base ligand and its complexes have been tested in vitro to evaluate their antibacterial activity against bacteria, viz., Escherichia coli, Staphylococcus aureus and Bacillus subtilis. It has been found that the complexes have higher activity than the corresponding free Schiff base ligand against the same bacteria.

Synthesis, structures, and antimicrobial activities of two cobalt(II) complexes [Co(L1)2(OH2)2] and [Co(L2)2]

“…[1][2][3][4][5][6] In recent years, metal complexes of Schiff bases have attracted considerable attention due to their remarkable biological activity, such as antifungal, antibacterial and antitumor property. [7][8][9] It has been shown that the Schiff base complexes derived from salicylaldehyde and its derivatives with primary amines, bearing the N 2 O, N 2 S, NO 2 or NSO donor sets, have interesting biological activity. [9][10][11][12] Furthermore, cobalt complexes in its varied oxidation states have become a central theme of current research because of their potentially useful properties in the realm of relevant scientific and technological fields.…”

“…[7][8][9] It has been shown that the Schiff base complexes derived from salicylaldehyde and its derivatives with primary amines, bearing the N 2 O, N 2 S, NO 2 or NSO donor sets, have interesting biological activity. [9][10][11][12] Furthermore, cobalt complexes in its varied oxidation states have become a central theme of current research because of their potentially useful properties in the realm of relevant scientific and technological fields. Recently, we have reported some Schiff base complexes and their application in biological area.…”

Two New Schiff Base Ni Ii and Cu Ii Complexes: Synthesis and Structures

“…[1][2][3] In recent years, metal complexes of Schiff bases have attracted considerable attention due to their remarkable biological activity, such as antifungal, antibacterial, and antitumor. [4][5][6] It has been shown that the Schiff base complexes derived from salicylaldehyde and its derivatives with primary amines, bearing the N 2 O, N 2 S, NO 2 , or NSO donor sets, have interesting biological activity. [6][7][8] Recent research indicates that the halide-substituent groups in aromatic rings of Schiff bases or aroylhydrazones can remarkably increase the antimicrobial activity.…”

“…[4][5][6] It has been shown that the Schiff base complexes derived from salicylaldehyde and its derivatives with primary amines, bearing the N 2 O, N 2 S, NO 2 , or NSO donor sets, have interesting biological activity. [6][7][8] Recent research indicates that the halide-substituent groups in aromatic rings of Schiff bases or aroylhydrazones can remarkably increase the antimicrobial activity. 9 As a continuation of our work on the synthesis and structures of Schiff base complexes, 10 in the present paper, the preparation and characterization of new nickel(II) and copper(II) complexes, [Ni(BCP) 2 …”

Synthesis of Some Novel and Biologically Active Schiff Bases Bearing a 1,3,4-Thiadiazole Moiety Under Acidic and PTC Conditions

“…[5][6][7][8][9][10][11] Furthermore, some Schiff bases are used in ion sensors and electrochemical sensors to empower detection with enhanced selectivity and sensitivity. 12,13 Due to the importance and diverse structural aspects of Schiff bases, several methods and procedures have been reported for synthesis of these compounds.…”