Synthesis, characterization, catalase functions and DNA cleavage studies of new homo and heteronuclear Schiff base copper(II) complexes

Mono-, Trinuclear Nickel(ii) and Copper(ii) Dioxime Complexes: Synthesis, Characterization, Catecholase and Catalase-Like Activities, Dna Cleavage Studies

“…8,[13][14] Multinuclear transition metal active sites that are involved in the catalysis of reactions vital to biological systems are being steadily recognized and studied. 15,16 Copper is a physiologically important element and many enzymes that depend on copper for their activity have been identified. Because of its biological relevance, a large number of copper(II) complexes have been synthesized and explored for their biological activities.…”

“…Because of its biological relevance, a large number of copper(II) complexes have been synthesized and explored for their biological activities. [16][17][18][19] Among these copper complexes, attention has been mainly focused on the copper(II) complexes of 1,10-phenanthroline ligand, due to their high nucleolytic efficiency 17 and numerous biological activities such as antitumor, 18 anti-candida 20 and antimicrobial 19,21 activities, etc. Nickel has been found in ureases 22,23 hydrogenases, CO dehydrogenases and coenzyme F430.…”

“…A number of copper containing multinuclear complexes have been studied catalase and catecolase like activity 15,16,25,26 but catalytically active complexes containing other transition metal ions such as Mn, Co or Ni 12,27,28 are also known. Catalase enzymes can dismute hydrogen peroxide, a reaction which is important for cell detoxification, and is linked to a variety of pathological consequences such as aging, diabetes and cancer.…”

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

“…On the other hand, the pBR322 DNA treated with the ligands (3)(4)(5)(6)(7)(8) are remarkably degrading the pBR322 DNA by oxidative (O 2 -dependent pathway) cleavage mechanism using the singlet oxygen as the reactive species [44,46]. These results are similar to that observed for some Cu(II) and Ni(II) complexes as chemical nuclease [47][48][49][50][51][52]. ) were determined by the picrate extraction method developed by Pedersen [53].…”

New Unsymmetric Dinuclear Copper(II) Complexes of Trans-disubstituted Cyclam Derivatives: Spectral, Electrochemical, Magnetic, Catalytic, Antimicrobial, DNA Binding and Cleavage Studies

“…The complexes show a sharp band in the region of 1630-1650 cm −1 due to the presence of -C=N in the complexes. 39 The effective Schiff base condensation is observed by the formation of this new peak and the disappearance of the ν -(C=O) peak at 1680 cm −1 in the complexes. The complex Cu 2 L 1a,b show sharp peak around 1100 cm −1 , which is split, clearly explains the presence of a coordinated perchlorate ion, 40 and in the other complexes Cu 2 L 2,3 the perchlorate peak around 1100 cm…”