Synthesis, characterization, biological (in vitro) activity, spectral and electrochemical behavior of N, S donors Schiff base ligand and their mixed-ligand copper (II)/cobalt (II) complexes with 5, 5’-dimethyl-2, 2’-bipyridine and 1, 10-phenanthroline

Abstract

Herein we reported the synthesis of (E)-N-(4- (thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide Schiff base ligand in an ethanolic medium. The Schiff base was derived from sulfaacetamide (N [4- (amino-phenyl)sulfonyl]acetamide) and 2- thiophenecarboxaldehyde and their mixed ligand copper(II)/cobalt(II) complexes (viz [Co(L)(5,5’- Me2bipy)(H2O)Cl]Cl, 1: [Co(L)(1,10-phen)(H2O)Cl] Cl, 2: [Cu(L)(5,5’-Me2bipy)(H2O)2], 3: and [Cu(L) (1,10-phen)(H2O)2] and 4: aromatic diimines (viz; 5,5’-dimethyl-2,2’-bipyridine, 1,10-phenanthroline) were prepared in 1:1:1 molar ratios and have been characterized by using different physico- chemical techniques. The investigation includes microanalysis, melting point, molar conductance, magnetic susceptibility, FTIR, UV-Visible and mass spectroscopy. Electrochemical and biological (in vitro) activities of Schiff base and their complexes have also been studied.