Synthesis, characterization, biological evaluation and molecular docking studies of N-functionalized derivatives of 2-aminobenzohydrazide

Synthesis, Characterization, Bioactivity Impacts of New Anthranilic Acid Hydrazones Containing Aryl Sulfonate Moiety as Fenamate Isosteres

“…In a study by Kausar et al ., the effects of the synthesized new fenamate isosteres on AChE and BChE were investigated. They reported that compounds N ‐(2 (2‐(4‐(trifluoromethyl)benzylidene) hydrazinecarbonyl)phenyl)thiophene‐2‐carboxamide and N ‐(2‐(hydrazinecarbonyl)phenyl)benzamide showed good inhibitory effect against AChE and BChE [17] …”

“…Therefore, finding and creating both a preventive and a curative treatment for AD is the researchers' ultimate goal. [32] The inhibitory effects of the novel compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) on AChE are shown in Table 2. The AChE inhibition profiles of the compounds evaluated here were quite interesting.…”

Design, synthesis, crystal structure, in vitro cytotoxicity evaluation, density functional theory calculations and docking studies of 2-(benzamido) benzohydrazide derivatives as potent AChE and BChE inhibitors

“…This compound 04 was further refluxed with stoichiometric amounts of differently substituted benzaldehyde derivatives using methanol as the solvent for two hours to obtain the hydrazone derivatives (05–13). 26 Washing of the obtained products was done using cold methanol to get clean compounds in good yields (nearly 90%) ( Scheme 1 ).…”

“…25 In this context, we developed both amide-and sulfonamide-derived benzohydrazide derivatives and found that the amide derivatives possessed good inhibitory activity against both AChE and BChE enzymes. 26 Keeping in view the previous efforts that were put to nd good inhibitors for AChE and BChE, more benzohydrazide derivatives with thiophene-2-carboxamide moiety attached at the ortho position were synthesized, which showed comparatively good potency against both these enzymes. 27 To further elucidate the importance of amide-derived benzohydrazide derivatives, we synthesized a series of 2-(benzamido) benzohydrazide derivatives.…”

Utilisation of bis-chloroacetamide derivative in the synthesis of new biologically active sulfide compounds

“…2-Aminobenzohydrazide derivative III (Figure 1) showed a greater than 90% scavenging percentage in their antioxidant activity experiment. 12 In addition, a good inhibitory activity was shown by 4-amino escitalopram benzohydrazide derivative IV (Figure 1) against cholinesterase AChE and BChE. 13 Furthermore, the most potent analgesic, ulcerogenic and anti-inflammatory activity was presented by quinazoline benzohydrazide derivative V (Figure 1).…”