Synthesis, characterization, antitumor potential, and investigation of mechanism of action of copper(ii) complexes with acylpyruvates as ligands: interactions with biomolecules and kinetic study

Abstract

Considering the urgency of finding a cure for vicious diseases such as tumors, we have synthesized and characterized a small series of new copper(ii) complexes with biologically important ligands such as acylpyruvate.

Facile synthesis of novel NNO-tethered copper(ii) complexes: characterization details, theoretical studies, promising enzyme-like activities, and biomolecular interactions

“…Copper-based anticancer drugs provide a broad therapeutic window against a wide range of cancer cell lines, with reduced off-target toxicity and fewer side effects, allowing them to circumvent the difficulties associated with platinum-based treatment options. 54–56 Therefore, systematic studies of circulating tumor (ct)DNA interactions with novel copper( ii ) complexes are crucial.…”

Synthesis of a new benzoate bridged NNO tethered copper(ii) complex: exploration of its bio, catalytic and anticancer activities

“…The anticancer properties of these copper complexes have recently piqued the curiosity of many researchers. Copper-based anticancer medications offer a large therapeutic window against a variety of cancer cell lines, 51–54 with reduced off-target toxicity and fewer side effects, enabling them to bypass the challenges posed by platinum-based therapy alternatives. 55,56 Furthermore, because drug distribution and uptake in the body are intertwined with plasma proteins, knowing drug pharmacology requires understanding their interaction.…”