Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents

Stevanović, Nevena; Mazzeo, Paolo Pio; Bacchi, Alessia; Matić, Ivana Z.; Crnogorac, Marija Đorđić; Stanojković, Tatjana; Vujčić, Miroslava; Novaković, Irena; Radanović, Dušanka; Šumar-Ristović, Maja; Sladić, Dušan; Čobeljić, Bofžidar; Anđelković, Katarina

doi:10.1007/s00775-021-01893-5

Cited by 8 publications

(12 citation statements)

References 71 publications

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“…The toxicity of Ni complexes with formula [Ni 2 L 1 2 (μ-1,1-N 3 ) 2 (N 3 ) 2 ]·4H 2 O ( 35 ), and ([Ni 2 L 2 2 ( μ -1,1-N 3 ) 2 (N 3 ) 2 ]·6H 2 O) ( 36 ) (H 2 L 1 Cl = (E)- N,N,N -trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, H 2 L 2 Cl = (E)- N,N,N -trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride) exhibit LC 50 0.86 and 0.82 mM, respectively (Table 2 ). The positive control (K 2 Cr 2 O 7 ) shows LD 50 0.077 mM [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…The toxicity of copper complexes [CuLCl](NO 3 ), [CuLCl](ClO 4 ) and [Cu 2 L 2 ( μ -1,1-N 3 ) 2 ](ClO 4 ) 2 ), ( 81–83 ) (H 2 LCl = (E)- N,N,N -trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride), as well as the salts Cu(ClO 4 ) 2 ·6H 2 O and Cu(NO 3 ) 2 ·3H 2 O was tested against A. salina with a range of LC 50 0.46 to 1.54 mM (Table 2 ) [ 41 ]…”

Section: Resultsmentioning

confidence: 99%

“…Copper salts: The LC 50 value is 0.24 mM for Cu(NO 3 ) 2 ·3H 2 O ( 99 ) (Table 2 ) [ 41 ]. Moreover, the LC 50 value of CuCl 2 ·2H 2 O ( 100 ) was 7.0 μM [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the LC 50 value of CuCl 2 ·2H 2 O ( 100 ) was 7.0 μM [ 49 ]. The LC 50 values of Cu(ClO 4 ) 2 ·6H 2 O ( 101 ) is 0.28 mM (Table 2 ) [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…The LC 50 values of zinc complexes, [ZnL 1 (NCS) 2 ]·2H 2 O ( 107 ) and [ZnL 2 (NCS) 2 ]·0.5MeOH ( 108 ) (HL 1 Cl ligand = (E)- N,N,N -trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, HL 2 Cl = (E)- N,N,N -trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, NCS = N-Chlorosuccinimide), are calculated at 1.27 and 0.98 mM, respectively (Table 2 ) [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

2022

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The pollution of aquatic ecosystems due to the elevated concentration of a variety of contaminants, such as metal ions, poses a threat to humankind, as these ecosystems are in high relevance with human activities and survivability. The exposure in heavy metal ions is responsible for many severe chronic and pathogenic diseases and some types of cancer as well. Metal ions of the groups 11 (Cu, Ag, Au), 12 (Zn, Cd, Hg), 14 (Sn, Pb) and 15 (Sb, Bi) highly interfere with proteins leading to DNA damage and oxidative stress. While, the detection of these contaminants is mainly based on physicochemical analysis, the chemical determination, however, is deemed ineffective in some cases because of their complex nature. The development of biological models for the evaluation of the presence of metal ions is an attractive solution, which provides more insights regarding their effects. The present work critically reviews the reports published regarding the toxicity assessment of heavy metal ions through Allium cepa and Artemia salina assays. The in vivo toxicity of the agents is not only dose depended, but it is also strongly affected by their ligand type. However, there is no comprehensive study which compares the biological effect of chemical agents against Allium cepa and Artemia salina. Reports that include metal ions and complexes interaction with either Allium cepa or Artemia salina bio-indicators are included in the review. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Copper salts: The LC 50 value is 0.24 mM for Cu(NO 3 ) 2 ·3H 2 O ( 99 ) (Table 2 ) [ 41 ]. Moreover, the LC 50 value of CuCl 2 ·2H 2 O ( 100 ) was 7.0 μM [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the LC 50 value of CuCl 2 ·2H 2 O ( 100 ) was 7.0 μM [ 49 ]. The LC 50 values of Cu(ClO 4 ) 2 ·6H 2 O ( 101 ) is 0.28 mM (Table 2 ) [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

2022

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Correlating Structure and KA² Catalytic Activity of Zn^II Hydrazone Complexes

Adejumo,

Danopoulou,

Zorba

et al. 2023

Eur J Inorg Chem

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Two new Zn(II) complexes bearing tridentate hydrazone‐based ligands with NNO or NNS donor atoms were synthesised and characterised by elemental analysis, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies, and single crystal X‐ray diffraction methods. These complexes, together with four previously synthesised analogues, having hydrazone ligands with a NNO donor set of atoms, were successfully employed as catalysts in the ketone‐amine‐alkyne (KA2) coupling reaction, furnishing tetrasubstituted propargylamines, compounds with unique applications in organic chemistry. DFT calculations at the CAM‐B3LYP/TZP level of theory were performed to elucidate the electronic structure of the investigated Zn(II) complexes, excellently correlating the structure of the complexes to their catalytic reactivity.

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Nickel(II) and nickel(III) thiosemicarbazone and hydrazone complexes: An unexpected journey

Jevtović,

Pevec,

Turel

et al. 2023

Inorganic Chemistry Communications

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Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents

Abstract: Synthesis and characterization .

Cited by 8 publications

References 71 publications

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

Correlating Structure and KA² Catalytic Activity of Zn^II Hydrazone Complexes

Nickel(II) and nickel(III) thiosemicarbazone and hydrazone complexes: An unexpected journey

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Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents

Abstract: Synthesis and characterization .

Cited by 8 publications

References 71 publications

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

Correlating Structure and KA2 Catalytic Activity of ZnII Hydrazone Complexes

Nickel(II) and nickel(III) thiosemicarbazone and hydrazone complexes: An unexpected journey

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Correlating Structure and KA² Catalytic Activity of Zn^II Hydrazone Complexes