Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Abstract

Mixed complexes of Ibuprofen-Pyrimethamine were synthesized using Cd(II) Co(II), Zn(II), and Mn(II). The mixed complexes were characterized based on some physicochemical and spectroscopic techniques such as infrared, elemental analysis, conductivity measurements, and magnetic moment. Based on the results obtained, the complexes were formulated as [M(L1)(L2)]Cl2, where M = metal ion, L1 = Pyrimethamine, L2 = Ibuprofen). The complexes were found to be non-electrolytes. The ligands act as bidentate towards the central metal ions with deprotonation occurring at the carboxylic group. The complexes were also analyzed by conductometric titration. Antimicrobial screening against the selected organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus megaterium and Serratia marcescens for the complexes alongside the free ligands were investigated. The antimalarial study was investigated for the compounds against Plasmodium berghei (NK 65 strain). It was observed that the complexes showed significant potentials against the studied organisms.

Toxicological and Antibacterial Studies of Mixed Amodiaquine-Anthranilic Acid Metal-Drug Complexes: Synthesis and Characterization

“…The proposed structure of the complexes are displayed in Figure 1. The elemental analysis indicated that the theoretical and experimental are in good agreement with each other 13,21,22 . They are stable at room temperature and in powdery form with melting point greater than 360ºC.…”

“…The decomposition temperature for the complexes were greater than 360 ℃. The molar conductance of the complexes are 70, 85, and 87 Ω -1 cm 2 mol -1 for Mn(II), Cu(II), and Cd(II) complexes respectively indicating that they are electrolytic in nature, while Ni(II) complex with a molar conductance of 24 Ω -1 cm 2 mol -1 is non-electrolyte 12,21,23 and [Mn(ANT)(AMO)Cl 2 ] complexes were found in an octahedral environment, [Ni(ANT)(AMO)] complex exhibited square planar geometry [11][12][13][14]21,24 . Hence, the proposed synthetic equation for the metal drug complexes can be shown as:…”

“…Based on the research work of Tella et al 12 , coordination complexes can be used as chemotherapy for the treatment of metal intoxication. Bamigboye and Ejidike 13 reported the characterization, antimalarial and antimicrobial activities of mixed ibuprofenpyrimethamine metal complexes. The antimalarial study of the compounds was screened against Plasmodium berghei (NK 65 strain), and showed that the complexes exhibited significant potentials against the studied organisms 13 .…”

“…Drugs combination improves the effectiveness of chemotherapeutic agents towards bacteria and parasite cell inhibitions 17 . It has also been sustained that combination therapy gives an effective action in bacteria resistant situation owing to previous research [10][11][12][13][14] would have an improved therapeutic action such as antibacterial and toxicological activities. The administration of the metal-drug samples to experimental animals (albino rats) was carried out in order to determine medical effect of the graded doses of the samples using biochemical parameters of the blood samples and essential organ like liver of these experimental animals.…”

Recent Advances in the Catalytic Applications of Chiral Schiff‐Base Ligands and Metal Complexes in Asymmetric Organic Transformations

“…[14] Hence, they are the essential compounds in the field of biochemistry and pharmaceutical chemistry. They are mostly used as potential drugs in the form of anti-cancer, [15][16][17][18][19] anti-microbial, [20][21][22][23][24] anti-tumour, [25,26] antimalarial, [27][28][29][30][31][32] anti-inflammatory, [33,34] anti-oxidant, [35][36][37][38][39] antipyret-ic agents, [40,41] etc. The bio-compatibility of Schiff base compounds is due to their ability to bind with the DNA.…”