Synthesis, Characterization, Antibacterial and Antifungal Evaluation of Novel Cyclohexanone Benzoylhydrazones

Abstract

A novel series of benzoyl hydrazones (2a-j) were synthesized and evaluated, in vitro, for antimicrobial activity against selected bacteria and fungi. The structures of the compounds were established by IR, 1 H-NMR, 13 C-NMR (APT), electrospray ionization mass spectrometry (ESI-MS) and microanalysis (C, H, N). All of the tested compounds, except for compound 2h, displayed weak antibacterial properties against Staphylococcus epidermidis ATCC 12228 and Staphylococcus aureus ATCC 29213. Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis.

Solvatochromism, Acidochromism and Photochromism of the 2,6-Bis(4-hydroxybenzylidene) Cyclohexanone Derivative

“…Chalcone derivatives containing the ketoethylenic group (-CO-CH=CH-) provide a rich source for the synthesis of optically active compounds [ 3 ]. These derivatives have great potential for applications due to their specific electronic structures (i.e., a completely delocalized electron system) [ 4 ], photophysical properties [ 5 , 6 , 7 ], and biological activities, such as being antimicrobial [ 8 ], antioxidant [ 9 ], anticonvulsant [ 10 ], inhibitors of inflammatory markers [ 11 ], and antifungal agent [ 12 ]. In recent years, dibenzylidene cyclohexanone derivatives have been used as corrosion inhibitors [ 13 ], fluorescent sensors for detecting Hg 2+ [ 14 ], and chromium ions in aqueous media [ 15 ].…”