Synthesis, characterization, antibacterial activity in dark and in vitro cytocompatibility of Ag-incorporated TiO2 microspheres with high specific surface area

Abstract

Postoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO]) and urea as the titanium source and precipitant, respectively. The molar ratio of silver (Ag) to TiO can be changed by varying the amount of silver nitrate (AgNO). The high specific surface area of the TiO microspheres combined with Ag particles (Ag/TiO) exhibit excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli. In addition, the Ag/TiO material in this work possesses satisfactory biological performance on MC3T3-E1 cells. The high specific surface area of Ag/TiO together with good antibacterial properties and cytocompatibility provide promising applications in dentistry, orthopedics, and other fields of medicine that use biomedical devices.

Catalytic CO Oxidation and H2O2 Direct Synthesis over Pd and Pt-Impregnated Titania Nanotubes

“…Thus, TiO2 with a specific surface area < 300 m 2 /g was observed most often [19][20][21][22][23]. Values of about 300 m 2 /g were, however, only reported for nanorods and microspheres [24,25], as well as for TiO2-SiO2 composite xerogels [26,27]. Table 1.…”

Photocatalytic TiO2 nanomaterials as potential antimicrobial and antiviral agents: Scope against blocking the SARS-COV-2 spread

“…Similarly, Ag-TiO 2 systems have been investigated for antimicrobial activities and excellent results have been reported for bacterial disinfection in light/ambient as well as in dark conditions due to the surface plasmon properties of Ag or antibacterial release of Ag ions respectively [ 27 , 40 ]. Weng et al [ 82 ] synthesized the Ag-TiO 2 system with higher surface area which exhibited excellent antibacterial properties against microbes/MC3T3-E1 cells as shown in Fig. 3 A.…”

Application of Antimicrobial Nanoparticles in Dentistry

“…Different antimicrobial NPs were developed such as Ag [89,90,91,92,93,94,95,96], copper (Cu) [95], ZnO [87,97,98], titanium dioxide (TiO 2 ) [99,100,101] and selenium (Se) [102]. AgNPs showed significant antimicrobial activity against Gram-negative and Gram-positive bacteria [86,103].…”

“…A previous study found that the toxicity of NPs had a strong correlation with the time, rather than with the concentration of antimicrobial NPs [19]. A favorable outcome was that the addition of antibacterial NPs made the original materials less toxic but more biocompatible [60,84,90]. In summary, the toxicity of antimicrobial NPs is affected by a variety of factors such as dosage, types, particle size, distribution, duration of action, interaction with other components and so on.…”