Synthesis, characterization and sustaining controlled release effect of mesoporous SBA-15/ramipril composite drug

Zhai, Qing-Zhou; Wu, Yanhua; Wang, Xiaohan

doi:10.1007/s10847-012-0222-9

Cited by 15 publications

(9 citation statements)

References 23 publications

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“…1. By observing the XRD diffraction peaks of the sample, it is found that these peaks are in good agreement with those reported in the literature (Zhai et al 2013) and have the typical characteristic peaks of SBA-15. Therefore, the prepared sample is SBA-15.…”

Section: Sample Characterizationsupporting

confidence: 87%

“…After it, cooling, washing, filtering and room temperature drying were carried on, white powder was obtained and calcined at 550 °C for 24 h in a muffle furnace. After the template was removed successfully, white powder SBA-15 mesoporous molecular sieve was obtained (Zhai et al 2013).…”

Section: Preparation Of Sba-15mentioning

confidence: 99%

“…Nanomesoporous material not only plays a role in catalytic reactions such as macromolecular adsorption, but also it is a good adsorbent for heavy metals, which has been used in the adsorption of Pb(II), Ni(II) ion (Ghorbani et al 2016) and Cu(II) ion (Dana and Sayari 2011). As a nanomesoporous adsorption material, SBA-15 (Zhai et al 2013) has large specific surface area and high adsorption capacity and it has obvious adsorption effect without adding any chemical reagents. Therefore, using SBA-15 to adsorb Cd 2+ in aqueous phase has the advantages of high efficiency, high speed, strong adaptability and easy operation.…”

Section: Introductionmentioning

confidence: 99%

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Efficient removal of cadmium(II) with SBA-15 nanoporous silica: studies on equilibrium, isotherm, kinetics and thermodynamics

Zhai

2019

Appl Water Sci

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Nanomesoporous silica SBA-15 was prepared by hydrothermal method. The samples were characterized by powder X-ray diffraction and scanning electron microscopy. The fibrous particles with a diameter of 333 ± 10 nm were obtained. Nanoporous mesoporous SBA-15 was used as an adsorbent to adsorb Cd 2+ in water body. The effects of conditions such as acidity were studied, and the optimized adsorption conditions were obtained. The results showed that when the pH value was 5.0, the temperature was 25 ± 1 °C and the adsorption time was 40 min, the nanomesoporous SBA-15 had the best adsorption effect for Cd 2+ and the adsorption rate was reached 73.28% and the adsorption capacity was 9.84 mg/g. Study found that the adsorption is the quasi-second-order kinetic model, which belongs to the Freundlich adsorption type. The results of adsorption thermodynamics showed that when the temperature is 25-55 °C, the adsorption is spontaneous exothermic reaction, ∆G 0 < 0, the adsorption enthalpy change ΔH 0 = − 54.732 kJ/mol, the adsorption entropy change ∆S 0 = − 129.343 J/(mol K). The effects of nitric acid and hydrochloric acid on desorption were investigated, respectively. The results showed that the desorption effect of 0.1 mol/L nitric acid as desorbent was better than that of hydrochloric acid. At desorption for 10 h, the desorption rate was the highest, reaching 65.56%.

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Section: Sample Characterizationsupporting

confidence: 87%

Section: Preparation Of Sba-15mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficient removal of cadmium(II) with SBA-15 nanoporous silica: studies on equilibrium, isotherm, kinetics and thermodynamics

Zhai

2019

Appl Water Sci

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“…In this regard, 70-95% of the hydrophobic drug Dasatinib, loaded in SBA-15 was released in just 2 h, independent of the porosity of the materials [44]. A controlled release was obtained by Qing-Zhou et al [45] with Ramipril, also a hydrophobic drug, having about 50% of the drug released after 5 h. Shahriarinour et al [46] found a THY release of about 6.8% during the first hour and the release increased to 95.1% after 4 days. The sustained release achieved in our loaded materials could be related to the amphipathic behaviour of THY resulting from the analysis of its chemical structure [47].…”

Section: Thy/sba-15 Loaded Pcl Fibersmentioning

confidence: 85%

Antibacterial Effect of Thymol Loaded SBA-15 Nanorods Incorporated in PCL Electrospun Fibers

et al. 2020

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For the effective management of infected chronic wounds, the incorporation of antimicrobial drugs into wound dressings can increase their local availability at the infection site. Mesoporous silicon dioxide SBA-15 is an excellent drug carrier with tunable drug release kinetics. In this work, synthesized SBA-15 loaded with the natural antimicrobial compound thymol (THY) was incorporated into polycaprolactone (PCL) electrospun nanofibers to obtain an advanced wound dressing. Rod-shaped particles with internal parallel channels oriented along the longitudinal axis (diameter: 138 ± 30 nm, length: 563 ± 100 nm) were loaded with 70.8 wt.% of THY. Fiber mats were prepared using these particles as nanofillers within polycaprolactone (PCL) electrospun fibers. The resulting mats contained 5.6 wt.% of THY and more than half of this loading was released in the first 7 h. This release would prevent an initial bacterial colonization and also inhibit or eliminate bacterial growth as in vitro shown against Staphylococcus aureus ATCC 25923. Minimal inhibitory concentration (MIC: 0.07 mg/mL) and minimal bactericidal concentration (MBC: 0.11 mg/mL) of released THY were lower than the amount of free THY required, demonstrating the benefit of drug encapsulation for a more efficient bactericidal capacity due to the direct contact between mats and bacteria.

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“…Pioneering work in use of periodic nanoporous silica nanoparticles for drug delivery was done by M. Valet Regí et al They studied the use of MCM-41 silica for controlled release of ibuprofen and the influence of surface morphology and its modification by amines to the release of the drug [14][15][16][17][18][19][20]. These works started intensive research and different drugs including antibiotics [21], drugs regulating blood circulatory disorders in the brain [22], antihypertensive drugs [23], anticancer drugs [24], antiviral drugs [25], vitamins [26], chemopreventive agents [27], antibacterial agents [28][29][30], non-steroidal anti-inflammatory drugs [31,32] were studied. In most of the studies silica with unidirectional channels of hexagonal 2D structure (MCM-41, SBA-15) was investigated.…”

Section: Introductionmentioning

confidence: 99%

Periodic 3D nanoporous silica modified by amine or SPION nanoparticles as NSAID delivery system

et al. 2016

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Nonsteroidal anti-inflammatory drug (NSAID) indomethacin (indo) was loaded into cubic nanoporous silica SBA-16 modified by amine groups (A-SBA-16) or hematite SPIONs (Fe-SBA-16). The kinetic of the indomethacin release into physiological solution with pH = 7.4 was studied. After 72 h the released amount represented 91 % of the loaded amount for the unmodified SBA-16 and 63 % for the amine modified one. To study vectored drug delivery to the affected body organs with the assistance of magnetic field, SBA-16 was modified by Fe 2 O 3 SPION nanoparticles and the magnetic properties of the sample were investigated by SQIUD magnetometry. The results show on superparamagnetic behaviour of the composite sample Fe-SBA-16 at room temperature with the value of effective magnetic moment m p * 384 l B . It was shown that the superparamagnetic behaviour of Fe-SBA-16 did not change after the indomethacin incorporation. The kinetic of the drug release from the Fe-SBA-16/indo sample was similar to the SBA-16/indo sample in the first 50 h. However, the total released amount after the 72 h was for the Fe-SBA-16/indo sample lower (68 % of the loaded amount), indicating the stronger interaction of the drug with the porous carrier.

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Synthesis, characterization and sustaining controlled release effect of mesoporous SBA-15/ramipril composite drug

Cited by 15 publications

References 23 publications

Efficient removal of cadmium(II) with SBA-15 nanoporous silica: studies on equilibrium, isotherm, kinetics and thermodynamics

Efficient removal of cadmium(II) with SBA-15 nanoporous silica: studies on equilibrium, isotherm, kinetics and thermodynamics

Antibacterial Effect of Thymol Loaded SBA-15 Nanorods Incorporated in PCL Electrospun Fibers

Periodic 3D nanoporous silica modified by amine or SPION nanoparticles as NSAID delivery system

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