Synthesis, Characterization and Study the Biological Activity for Some New Heterocyclic Derivative from 4,5-dichloro Imidazole

Abstract

Creating a multi-step method for synthesizing heterocyclic compounds is the goal of this research. The first step involves reacting 4,5-dichloro-2- phenylenediamine with 3- amino- 4-“hydroxybenzoic acid to produce an imidazole derivative (1), which then reacts with salicyldehyde to produce the azo compound (2). Two, a Schiff base derivative is produced via a reaction with p-chloro aniline (23). Final steps involve reactions (3) with chloroacetyl chloride, alanine, sodium azide, thioglycol acid, anthranilic acid, and maleic anhydride, yielding beta-lactam derivatives (4), imidazolidine (5), tetrazol(6), thiazolidine (7), hydroquinazoline”(8), and oxazepine (9), respectively. The spectroscopic techniques of fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1HNMR) have been used to identify all of the compounds that have been prepared; next, the compounds’ biological effects on two types of cancer have been investigated.