Synthesis, Characterization, and Reactivity of Platinum Cysteinato and Related Thiolato Complexes: Molecular Structure of Pt2(.mu.-N-acetyl-L-cysteine-S)2(bpy)2

Synthesis and crystal structure of thiolate-bridged dinuclear platinum(II) complexes

“…The average Pt-S bond lengths in 1 and 2 are equal to ~2.3 Å (Table 2), which is consistent with the data for structurally related complexes containing both aliphatic [24] and aromatic [25,26] ammine ligands. The average Pt-N bond length in 1 and 2 (~2.03 Å) approaches that in platinum complexes with aromatic amines [25][26][27][28]. The Pt-N bond in platinum complexes with aliphatic amines (in the trans position with respect to thiolate ligand) is longer (2.3-2.4 Å) [24] due to stronger trans-effect of thiols, which is comparable to the trans-effect of aromatic amines [21].…”

“…2-Aminoethanthiolate in complex 3 is a tetradentate μ 3 -bridging ligand chelating platinum atom. The average Pt-N bpy distance (~2.03 Å, Table 3) is consistent with the data for structurally related complexes [25][26][27][28]. It is interesting that the Pt-N aet bond is short (2.04 Å), which is more typical of aromatic ammine ligands.…”

Chemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-L-cysteine

“…The biological activities of NAC were recently described [15][16][17][18]. The synthesis, characterization, and reactivity of a dinuclear platinum(II) complex with NAC and bipyridine were also described, where NAC is coordinated to Pt(II) through sulfur and bridges the two metal centers [19]. More recently, new palladium(II) and platinum(II) complexes with NAC, in the anionic form, were synthesized in our laboratories [20,21].…”

Novel polynuclear platinum adducts detected during the reactions of [Pt(Met-S,N)Cl 2 ] with γ-glutathione and l -cysteine

“…The stable nitrogen chelates in these model complexes limited the polymerization process to a certain extent. Jensen and co-workers [21][22][23] have structurally characterized a binuclear compound [Pt 2 (lAcCys-S) 2 (bpy) 2 ] using the sterically crowded bipyridyl ligand (bpy), however, this model shares little similarity to cisplatin.…”