Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

Abstract

2-Octylsuccinic acid and its copolyanhydrides with sebacic acid have been synthesized by melt polycondensation, and were characterized by Fourier transform infrared spectroscopy, 1 H NMR, gel permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. In vitro studies showed that all copolymers are degradable in phosphate buffer at 37 • C. The release profiles of the hydrophilic model drug ciprofloxacin hydrochloride follow first-order release kinetics.