Synthesis, characterization and pharmacological studies of copper complexes of flavone derivatives as potential anti-tuberculosis agents

Joseph, J.; Nagashri, K.; Suman, A.

doi:10.1016/j.jphotobiol.2016.06.033

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…The same DNA binding capability through intercalation mode was also reported for a series of new copper complexes of hydroxyflavone derivatives (Joseph et al . ). Studies performed by Ayman et al.…”

Section: Introductionmentioning

confidence: 97%

Synthetic flavonoids with antimicrobial activity: a review

et al. 2019

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The emergence of drug-resistant microbes left us with a great need for new antimicrobial agents. Flavonoids, with their wide range of biological activities, are good candidates in this respect. Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and even killing microbes at concentrations below 1 lg ml À1 . The substitution pattern of these flavonoids often includes hydroxy groups, halogens or other heteroatomic rings, such as pyridine, piperidine or 1,3-dithiolium cations. However, the great variety in substituents makes it difficult to draw any definitive conclusion regarding their structureactivity relationship.

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Section: Introductionmentioning

confidence: 97%

Synthetic flavonoids with antimicrobial activity: a review

et al. 2019

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“…[3][4][5] Previous research has shown that the presence of an azo chromophore in the heterocyclic ring enhances the pharmacological activity. [6] Among the heterocyclic azo dyes, those containing the thiazole moiety piqued chemists' interest because of their significance in the pharmacological activity, [7][8][9][10] so thiazole-based azo dyes could be used as pioneering drug molecules for the treatment of multiple diseases. Thiazolylazo dyes are attractive to chemists due to their exceptional applications in manufacturing and daily life [11] as well as their specific using in chromatographic columns, [12] data storage strategies, [13,14] clothing, leather, foodstuffs, cosmetics, and plastics coloring.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and multifunctional applications of novel metal complexes based on thiazolylazo dye

El‐Nahass

Bakr

El‐Gamil³

et al. 2022

Applied Organom Chemis

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Herein, a novel ligand, namely, N,N-dimethyl-4-((4-(pyridin-2-yl)thiazol-2-yl) diazenyl)aniline, and its solid Mn (II), Co (II), Ni (II), and Cu (II) complexes have been synthesized and characterized. The photophysical properties of the thiazolyl azo ligand, L, have been investigated in various solvents of different polarities. The absorption and fluorescence maxima of the ligand show a strong dependence on the solvent polarity. The metal ions sensing response to Mn (II), Co (II), Ni (II), and Cu (II) ions were also investigated in ethanolic solutions. The novel solid complexes of hexacoordinate Mn (II), Co (II), Ni (II), and Cu (II) of the ligand have the molar ratio 2:1 (M:L) and general chemical formula [M 2 (L)(H 2 O) 4 Cl 4 ]ÁnH 2 O. The presence of metal-metal interaction was proved by the low magnetic moment values μ eff of metal complexes. The UV-Vis spectra of the ligand and its metal complexes displayed bands characteristic to different types of transitions inside the molecules. The metal complexes show additional absorption bands of very low intensity around 650-690 nm attributed to d-d transitions within the metal ion indicating octahedralgeometry. The geometry of the ligand and its complexes was also theoretically confirmed using the DMOL3 program and density functional theory (DFT). The free ligand and its metal complexes have been studied for their DNA-binding properties using steady-state absorption and emission techniques. They demonstrated successful binding properties against CT-DNA in an intercalative mode.Additionally, the ligand and its metal complexes have also been successfully applied to polyester fabrics as disperse dyes. Multifunctional properties such as color representation, colorimetric data (L*, a*, b*, C*, h*, K/S), and fastness properties of the dyed samples have been discussed and evaluated in detail. These dyes have proven their efficiency in dyeing polyester fabrics, as they give satisfactory results in fastness properties, colorimetric data. Moreover, the antioxidant and antitumor activities for the synthesized compounds were evaluated.

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Design, Synthesis, Characterization, and Antimicrobial Properties of New Azo Disperse Dyes Incorporating Quinazolinone-Pyrazolone Moieties and Their Applications for Dyeing of Polyester Fabrics

Ibrahim,

Selim,

Sakr

et al. 2024

Fibers Polym

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The current study outlines a straightforward and efficient method for creating new quinazolinone disperse dyes based on pyrazolone moieties, starting with quinazolinone and a variety of substituted pyrazolone as couplers. The synthesized dyes were characterized using a variety of spectroscopic and analytical methods. The synthesized dyes' ultraviolet–visible spectra showed bands brought on by several molecular transitions. We investigated in detail the multifunctional characteristics such color representation, dyeing duration, concentration, pH, buildup, and fastness properties of the dyed samples. Fastness properties and colorimetric data showed satisfactory results, demonstrating the effectiveness of these dyes in dyeing polyester fabrics. A pH of 5 and a dyeing temperature of 130 °C were the ideal conditions for dyeing polyester fabrics. Additionally, an ultraviolet protection factor test was performed on the dyed fabrics, and the results showed that these dyes provide the best UV protection. These dyes are suitable for industrial dyeing applications since they are easy to manufacture and scale up. Additionally, in-vitro testing was done to determine the dyes' antibacterial effectiveness against various bacteria and fungi. The antibacterial activity of the dyes was moderate to very good against both Gram-positive and Gram-negative bacteria, as well as fungi.

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Synthesis, characterization and pharmacological studies of copper complexes of flavone derivatives as potential anti-tuberculosis agents

Cited by 9 publications

References 40 publications

Synthetic flavonoids with antimicrobial activity: a review

Synthetic flavonoids with antimicrobial activity: a review

Synthesis, characterization, and multifunctional applications of novel metal complexes based on thiazolylazo dye

Design, Synthesis, Characterization, and Antimicrobial Properties of New Azo Disperse Dyes Incorporating Quinazolinone-Pyrazolone Moieties and Their Applications for Dyeing of Polyester Fabrics

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