Synthesis, Characterization and Pharmacological Screening of Some Novel Benzimidazole Derivatives

Abstract

The reaction of o-phenylenediamine with anthranillic acid yield compound 2-(1H benzo[d]imidazol-2-yl) aniline (1). The compound (1) was condensed with Chloroacetyl chlorides in the presence of dry benzene to get compound 2-chloro-N-[2-(2,3-dihydro-1Hbenzimidazol-2-yl)phenyl]acetamide.Further it to then treated with KSCN to getan intermediate compound then reacted with corresponding aromatic aldehyde yield compound 5 benzylidene-3-[2-(2,3-dihydro-1Hbenzimidazol-2-yl)phenyl]-2-imino-1,3-thiazolidin-4-one. The compounds were synthesizedin good yields and their structures were confirmed by IR, 1 H-NMR-spectral dataand elemental analysis. Antimicrobial activity against bacteria and fungi was studied. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram-positive (S. aureus and B. subtilis), Gram-negative (E. coli, S. typhi) bacteria. Some derivatives showed remarkable activity comparable to that of standard against Gram-positive and Gram-negative bacteria. The results of preliminary biological tests showed that of these compounds possess good biological activities.

Benzimidazoles and Imidazo[1,2-a]pyridines : Biological Activities, Method of Synthesis and Perspectives on Combination of Deuce Pharmacophore

“…[32]- [34] Some of these compounds are used to fight parasitic diseases such as helminthiases. This is the case for Flubendazole, Mebendazole, Albendazole and Thiabendazole.…”

Benzimidazole-modified polyaniline micro-shells for electrochemical detection of cadmium in aqueous solution

“…The benzenoid and quinoid characteristic C=C stretching vibrations are now observed at 1506 and 1570 cm -1 , respectively, and the typical C-N stretching vibration of the polyaniline backbone now appears at 1302 cm -1 . The peak at 1670 cm -1 corresponds to the characteristic C=N stretching vibration of benzimidazole [21], and the peaks at 1459 and 1220 cm -1 are due to the C=C [22] and C-N [23] stretching vibrations, respectively, of benzimidazole. Altogether, these findings prove the presence of the benzimidazole entity as the side chain in the synthesized polymer.…”

Recent achievements in the synthesis of benzimidazole derivatives

“…The results of preliminary biological tests showed that all compounds exhibited significant anthelmintic activity. 5 Vilasrao et al described the synthesis of a library of 2-substituted benzimidazoles and the evaluation of their anthelmintic activity against the adult earthworm E. fetida . Among them, compounds 23–25 exhibited excellent anthelmintic activities which are comparable to that of standard albendazole ( Fig.…”