Synthesis, characterization, and pepsin inhibition study of Au(III)–3-(2′-thiazolylazo)-2,6-diaminopyridine complex

Piyasaengthong, Akkharadet; Boonyalai, Nonlawat; Suramitr, Songwut; Songsasen, Apisit

doi:10.1016/j.inoche.2015.06.025

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Also transition metal complexes of azo schiff bases are found to be useful as anticancer agents, antibacterial [7][8][9][10], as excellent homogeneous and heterogeneous-phase catalysts [11], and as chemical sensors [12]. Cancer, known as the malignant tumor or malignant neoplasm, is the kind of diseases characterized by out-of-control cell growth [13]. Around a world, big number of people are diagnosed with cancer each year, and most of a patients die from it [14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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New heterocyclic azo-schiff base dye (L2) have been synthesized from a reaction of 4-(dimethylamino)benzaldehyde with (E)-5-((1H-benzo[d]imidazol-2-yl) diazenyl) -2amine-4,6-dimethylpyridin (L1) . A new class of Ni(II), Pd(II), and Pt(IV) complexes of azo-schiff base of the type [Ni(L2)2Cl2], [Pd(L2) Cl2] , and [Pt-2amine-4,6-dimethylpyridin. Both ligand and its metal complexes were characterized by the spectroscopic and analytical methods such as mass spectral, 1 H-NMR, FT-IR, UV-Visb.,X-ray, TGA and SEM, elemental analysis, molar conductance measurements and magnetic susceptibility., spectral studies suggest the mole ratio [M:L] was [1:2] for Ni(II) and Pt(IV) metal ions, but [1:1] for Pd(II) metal ion. The structures of theses complexes were elucidated on the basis of different techniques suggest the structures of the prepared metal complexes octahedral geometry for the Ni(II) and Pt(IV) complexes and square planar geometry for the Pd(II) complex. The antibacterial activity of the ligand and prepared metal complexes was also studied against gram positive Staphylococcus aureus and gram negative bacteria Escherichia coli, the antifungal activity of the azo-schiff base and metal complexes against the fungi Alternaria. It is found that some of the complexes are quite effective against fungi Alternaria. In this study the cytotoxicity of Pd(II)-complex on human (PC3) cancer and normal cells were studied using MTT assay. Pd(II)-complex showed selective cytotoxicity against cancer cell line with IC50 = 450 μg/ml, while it was very safe on normal cells line with IC50 = 14554885 μg /ml, respectively for human cells .The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of medicine and Pharmacy against prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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“…Complexes of TAR and TAC are formed in a similar way due to the presence of a hydroxyl group in the structure (Karipcin et al, 2010). 3-[2-(1,3-Thiazol-2-yl)diazen-1-yl]pyridine-2,6diamine monohydrate (Chotima et al, 2018) has been used as a chelating ligand to form a complex with Au III ion (Piyasaengthong et al, 2015). The crystal structure is stabilized by hydrogen bonding between the amine group, water and the thiazole nitrogen atom along withinteractions between pairs of pyridine rings and pairs of thiazole rings, resulting in the formation of a layered structure.…”

Section: Database Surveymentioning

confidence: 99%

Crystal structure of 3-methoxy-4-[2-(thiazol-2-yl)diazen-1-yl]aniline monohydrate

et al. 2019

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In the title hydrated azo dye, C10H10N4OS·H2O, the benzene and thiazole, are nearly coplanar, with a dihedral angle between their mean planes of 4.69 (17)°. The aromatic rings on the –N=N– moiety exhibit a trans configuration. The crystal structure features many types of intermolecular interactions involving all the functional groups – strong hydrogen bonds (N...H and O...H), weak hydrogen bonds (C—H...O and C—H...N), C—H...π and π–π interactions – resulting in the formation of a three-dimensional framework.

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“…In this regard, zinc complexes with polydentate chelating thiazolylazo ligands have been prepared as luminescence probes for selectively sensing phosphates (Hens et al, 2015). Recently, Piyasaengthong et al (2015) reported the synthesis of a gold(III) complex of 3-(2 0 -thiazolylazo)-2,6-diaminopyridine and investigated its pepsin inhibition.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of 3-[2-(1,3-thiazol-2-yl)diazen-1-yl]pyridine-2,6-diamine monohydrate

et al. 2018

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Synthesis, characterization, and pepsin inhibition study of Au(III)–3-(2′-thiazolylazo)-2,6-diaminopyridine complex

Cited by 6 publications

References 15 publications

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Crystal structure of 3-methoxy-4-[2-(thiazol-2-yl)diazen-1-yl]aniline monohydrate

Crystal structure of 3-[2-(1,3-thiazol-2-yl)diazen-1-yl]pyridine-2,6-diamine monohydrate

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