Synthesis, characterization and medical efficacy (hepatoprotective and antioxidative) of albendazole-based copper(II) complexes – an experimental and theoretical approach

Ibrahim, Mohamed M.; Ramadan, Abdel-Motaleb M.; El‐Sheshtawy, Hamdy S.; Mohamed, Mahmoud A.; Soliman, Mohamed Mohamed; Zayed, S. I. M.

doi:10.1080/00958972.2015.1093124

Cited by 20 publications

(7 citation statements)

References 42 publications

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“…The ground state will be 2 A 1g , which is a combination of d z 2 and d x 2 – y 2 orbitals ( Garribba and Micera, 2006 ; Lakshmi et al, 2012 ). Moreover, the nature of binding to the SCZ ligand was calculated by g av = (g‖ + 2 g ┴ )/3 ( Ibrahim et al, 2015 ) and was 2.14< 2.3, which indicated a highly covalent character of the metal–ligand bond.…”

Section: Resultsmentioning

confidence: 99%

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

et al. 2021

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In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized. The chemical structure of each complex was characterized using elemental analysis (CHN), IR spectroscopy, UV–Vis spectroscopy, thermogravimetric analysis (TGA), and electronic paramagnetic resonance (EPR) spectroscopy. IR spectra indicated that the donor atoms were one sulfonyl oxygen atom and one pyrazine nitrogen atom, which associated with the metal ions to form a stable hexagonal coordination ring. The metal–ligand stability constant (Kf) revealed that Cu(II) and Ni(II) have good coordination stability among the metal compounds. Theoretical studies using DFT/B3LYP were performed to further validate the proposed structures. The obtained results indicated that Cu(II) has a trigonal bipyramidal geometry, whereas Fe(II), Co(II), and Ni(II) have an octahedral structure, while Zn(II) has a tetrahedral arrangement. The bio-activities of the characterized complexes were evaluated using DNA binding titration and molecular docking. The binding constant values for the metal complexes were promising, with a maximum value for the copper metal ion complex, which was 9 × 105 M-1. Molecular docking simulations were also carried out to evaluate the interaction strength and properties of the synthesized metal complexes with both DNA and selected cancer-relevant proteins. These results were supported by in vitro cytotoxicity assays showing that the Cu(II) and Ni(II) complexes display promising antitumor activity against colon and breast cancer cell lines.

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Section: Resultsmentioning

confidence: 99%

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

et al. 2021

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“…41 Therefore, the ground state will be d x 2 Ày 2 and has a highest half-occupied orbital that repels the ligand in the equatorial plane. 42,43 The g av value, calculated by the equation g av = (g 8 + 2g > )/3, 44,45 was 2.14 and indicates a covalent environment around the Cu(II) metal ion. 46 To study the exchange interaction between the Cu(II) ions in a powder solid sample, the G value was computed using 42,47 G = (g 8 À g e )/(g > À g e ) According to the reported literature, if G is between 3 and 5, then the magnetic environment in the cell is equivalent; if 5 o G o 3, then the exchange coupling in the unit cell is not equivalent.…”

Section: Electron Paramagnetic Resonance Analysis (Epr)mentioning

confidence: 99%

“…48 The calculated value of G = 4.27 reflects that the exchange interaction is negligible between the Cu(II) ions. 44,48 3.6. Thermal analysis (TGA)…”

Section: Electron Paramagnetic Resonance Analysis (Epr)mentioning

confidence: 99%

Synthesis and theoretical calculations of metal-antibiotic chelation with thiamphenicol:in vitroDNA and HSA binding, molecular docking, and cytotoxicity studies

et al. 2021

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“…Natural enzymes have huge molecular weights and hence cannot penetrate through the cell membrane, resulting in a local effect. As a result, the idea of synthesizing metal complexes that functionally mimic the active site of SOD has emerged and well developed [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…As a part of our on-going research on the biological activities of several mononuclear nickel(II) and copper(II) complexes [4][5][6][7][8][9][10]19] and as a continuation to the work on the synthesis and structures of metal complexes of the drug 5,5-diethlybarbiturate (Barb), which has sedative-hypnotic activity [7]. Herein,…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, and X-ray Structural Characterization of Mixed Tetraamine-Barbitone Nickel (II) Complex Grafted g-C3N4 for Oxidative Stress and Cytotoxic Activities

Ibrahim

Meral

Abdou

et al. 2022

Preprint

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A new mixed ligand complex, viz., [Ni(Tren)(Barb)(H2O)](Barb)(Barb-H)•2H2O (NiC) {Tren = tris(2-aminoethyl)amine and Barb = 5,5-diethlybarbiturate} has been synthesized and characterized. The nickel(II) complex was grafted to g-C3N4, forming NiC@g-C3N4. The obtained NiC complex and its hybrid material NiC@g-C3N4 were characterized by means of FT-IR, TGA-DSC, UV-vis., SEM-EDX, and XRD. Single crystal X-ray crystallography suggests that NiC exhibits NiN5O octahedral geometry. The results also show that the complex molecules are connected via N–H××××O hydrogen bonds. The complex NiC and its NiC@g-C3N4 composite showed cytotoxic effects on in vivo experiments. They also showed an increase in tissue damage markers that are represented by the increase in tissue levels of malondialdehyde (MDA) in brain, liver, kidney and heart. In parallel, both materials showed inhibitory activity for examined antioxidants such as glutathione-S-transferase (GST), superozide dismutase (SOD), glutathione (GSH), glutathione reductase (GSH-R). The destructive effects were clearer for the NiC@g-C3N4 composite compared to in liver, brain and kidney, respectively. The grafting of NiC complex in g-C3N4 is responsible for improving the catalytic activity, which is due to the synergistic effect of both components and facile recovery, as well recycling of the catalyst.

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Synthesis, characterization and medical efficacy (hepatoprotective and antioxidative) of albendazole-based copper(II) complexes – an experimental and theoretical approach

Cited by 20 publications

References 42 publications

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

Synthesis and theoretical calculations of metal-antibiotic chelation with thiamphenicol:in vitroDNA and HSA binding, molecular docking, and cytotoxicity studies

Synthesis, Spectral, and X-ray Structural Characterization of Mixed Tetraamine-Barbitone Nickel (II) Complex Grafted g-C3N4 for Oxidative Stress and Cytotoxic Activities

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