Synthesis, characterization and magnetostructural correlation studies on three binuclear copper complexes of pyrimidine derived Schiff base ligands

Gupta, Sumana; Pal, Sachindranath; Barik, Ashok K.; Hazra, Arijit; Roy, Somnath; Mandal, Tarak Nath; Peng, Shie‐Ming; Lee, Gene‐Hsiang; Fallah, M. Salah El; Tercero, Javier; Kar, Susanta Kumar

doi:10.1016/j.poly.2008.05.009

Cited by 46 publications

(8 citation statements)

References 66 publications

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“…The Cu(II) chelate presented a broad band at 752 nm attributed to 2 B 1g → 2 A 1g transition, supporting a square planar geometrical arrangement around the Cu centre. A band appeared at 359 nm, assigned to n → π* transition, while the band appearing at 486 nm is due to ligand‐to‐metal charge transfer . The recorded magnetic moment (room temperature) of the Cu(II) complex was determined to be 1.76 BM.…”

Section: Resultsmentioning

confidence: 98%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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The azo dye ligand 4‐(5‐chloro‐2‐hydroxyphenylazo)‐N‐thiazol‐2‐ylbenzenesulfonamide (H2L) formed by the coupling reaction of sulfathiazole and p‐chlorophenol was synthesized and characterized using elemental analysis and Fourier transform infrared (FT‐IR) as well as UV–visible spectra. Nano‐sized divalent Cu, Co, Ni, Mn and Zn complexes of the synthesized azo dye ligand were prepared and investigated using various spectroscopic and analytical techniques. Elemental and thermal analyses indicated the formation of the Cu(II), Ni(II) and Mn(II) complexes in a molar ratio of 1:2 (L:M) while Co(II) and Zn(II) complexes exhibited a 1:1 (M:L) ratio. FT‐IR spectral studies confirmed the coordination of the ligand to the metal ions through the phenolic hydroxyl oxygen, azo nitrogen, sulfonamide oxygen and/or thiazole nitrogen. The geometric arrangements around the central metal ions were investigated applying UV–visible and electron spin resonance spectra, thermogravimetric analysis and molar conductance measurements. X‐ray diffraction patterns revealed crystalline nature of H2L and amorphous nature of all synthesized complexes. Transmission electron microscopy images confirmed nano‐sized particles and their homogeneous distribution over the complex surface. Antibacterial, antifungal and antitumour activities of the investigated complexes were screened compared with familiar standard drugs to confirm their potential therapeutic applications. The Cu(II) complex showed IC50 of 3.47 μg ml−1 (5.53 μM) against hepatocellular carcinoma cells, which means that it is a more potent anticancer drug compared with the standard cisplatin (IC50 = 3.67 μg ml−1 (12.23 μM)). Furthermore, the Co(II), Ni(II), Cu(II) and Zn(II) complexes displayed IC50 greater than that of an applied standard anticancer agent (5‐flurouracil) towards breast carcinoma cells. Hence, these complexes can be considered as promising anticancer drugs. The mode of binding of the complexes with salmon serum DNA was determined through electronic absorption titration and viscosity studies.

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Section: Resultsmentioning

confidence: 98%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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“…The Cu1⋯Cu2 distance inside the dimeric unit is 3.540(24) Å, similar to those in μ 2 -thiolate bridged CuĲII) dimers. [47][48][49][50][51][52][53][54][55][56][57] Noticeably, three deprotonated ligands in the [Cu 2 ĲL) 3 ] + cation display two kinds of coordination modes: two ligands coordinate to two Cu atoms in an expected N 2 S tridentate manner, while the last one serves as a tetradentate donor with two N atoms (pyridine N atom, imine N atom) adopting a normal chelating mode and S bridging mode (μ 2 ) linking two metal centers. The C-S distances range between 1.738(13) and 1.767(12) Å, being within the normal range of a C-S single bond, indicating that the ligands are coordinated in their deprotonated thiolate form.…”

Section: Chemistrymentioning

confidence: 99%

Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities

et al. 2017

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In this paper, synthesis and characterization of metal complexes [Cu(L)]ClO (), [Ga(L)]NO·2HO () and [In(L)]NO·HO () (HL = 2-acetylpyridine (4)-phenylthiosemicarbazone) was carried out, including elemental analysis, spectral analysis (IR, UV-vis, NMR), and X-ray crystallography. Complex contains one S-bridged binuclear [Cu(L)] unit, where two Cu atoms display diverse coordination geometries: one being square planar geometry and the other octahedral geometry. Both and are mononuclear complexes, and the metal centers in and are chelated by two NNS tridentate ligands possessing a distorted octahedral geometry. Biological studies show that all the complexes possess a wide spectrum of modest to effective antibacterial activities and remarkable cytotoxicities against HepG2 cells, and , in particular, with an IC value of 0.19 ± 0.06 μM, is 113-fold and 28-fold more cytotoxic than HL and the antitumor drug mitoxantrone, respectively. In addition, exhibits excellent photoluminescence properties. Upon the addition of equiv of In ions, a remarkable fluorescence intensity of HL and fluorescent color change (from transparent to light-green) could be observed with 365 nm light, indicating that this ligand may be used as a promising colorimetric and fluorescent probe for In detection.

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“…Indeed, the strong energy created by a very extensive hybrid, organic and inorganic, interface plays also a preponderant role. A lot of properties such as optical properties, separation, catalysis, photoluminescence, magnetism, conductivity, and ferroelectricity are thus subject to modulation of [1][2][3][4]. In addition, these materials are rich in hydrogen-bonds which are of great importance for biological processes [5]; they are energetically weaker than the covalent bonds, but their cumulative effect reinforces and maintains the three-dimensional shape of the crystalline structures of these materials.…”

Section: Introductionmentioning

confidence: 99%

Hirshfeld surface analysis, crystal structure and physicochemical studies of a new Zn(II) complex with the 2,6-dimethylpyrimidin-4-(1H)-one ligand

Klai

Jelsch²,

Lefèbvre

et al. 2020

Solid State Sciences

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A new Zn(II) complex with the monodentate ligand 2,6-dimethylpyrimidin-4-(1H)-one, [ZnCl(C6H8N2O)2H2O]NO3.H2O, has been prepared and characterized by single crystal X-ray diffraction, elemental analysis, CP-MAS NMR and IR spectroscopy. The Zn(II) cation is tetracoordinated, in a distorted tetrahedral fashion, by two nitrogen atoms of two organic ligands, one water oxygen atom and one chlorine atom. In the atomic arrangement, the [ZnCl(C6H8N2O)2H2O] + neighbor complexes are connected to each other via O-H….O, O-H…Cl and N-H…O hydrogen bonds to form a ribbon running along the b-axis direction. The ribbons are interconnected by the nitrate anions via O-H…O and N4-H…O hydrogen bonds to form layers parallel to (102) plane. Intermolecular interactions were investigated by Hirshfeld surfaces. Globally, the structure is maintained primarily by the metal atom coordination as well as strong and weak (O,N,C)-H…O hydrogen bonds and C-H… interactions. Besides a few strong electrostatic interactions (coordination and H-bonds), the nitrate and chloride anions are surrounded by many electropositive CH3 groups. The 13 C and 15 N CP-MAS NMR spectra are discussed and the vibrational absorption bands were identified by infrared spectroscopy. Electronic properties such as HOMO and LUMO energies were derived.

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Synthesis, characterization and magnetostructural correlation studies on three binuclear copper complexes of pyrimidine derived Schiff base ligands

Cited by 46 publications

References 66 publications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities

Hirshfeld surface analysis, crystal structure and physicochemical studies of a new Zn(II) complex with the 2,6-dimethylpyrimidin-4-(1H)-one ligand

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