Synthesis, characterization, and in vitro and in vivo evaluation of a novel pectin–adriamycin conjugate

Tang, Xiaohai; Xie, Ping; Ding, Yi; Chu, Liang‐Yin; Hou, Jing-Ping; Yang, Jinliang; Song, Xin; Xie, Yongmei

doi:10.1016/j.bmc.2009.12.076

Cited by 21 publications

(12 citation statements)

References 39 publications

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“…In particular, its primary amine group has induced irreversible cardiotoxicity. Modification to this primary amine group has been reported to reduce its toxicity on cardiovasculature (36). In addition, multidrug resistance induced by frequent use of ADM is another problem that significantly limits its clinical application.…”

Section: Discussionmentioning

confidence: 99%

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

Cao

Cui

et al. 2013

Cancer Research

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Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy-D-glucose and succinic acid (2DG-SUC-ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG-SUC-ADM for targeted cancer therapy. Cancer Res; 73(4); 1362-73. Ó2012 AACR.

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Section: Discussionmentioning

confidence: 99%

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

Cao

Cui

et al. 2013

Cancer Research

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“…In vivo evaluation of these devices demonstrated a suitable bioavailability, without any premature drug release in the small intestine or in the stomach medium. Besides, pectin also can be chemically cross-linked with anti-cancer drugs to create a pro-drug, as observed in Tang and coworkers study (175). Here, authors obtained an injectable novel pectin-adriamycin conjugate which was synthesized by attaching adriamycin to low-methoxylated pectin via an amide linkage.…”

Section: Pectin -Based Systems With Anticancer Applicationsmentioning

confidence: 93%

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

Martı́nez

Benito²,

Pérez³

et al. 2016

CPD

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Cancer has become one of the main causes of death in developed countries, and it is expected to be declared as the disease with the highest worldwide morbidity and mortality indexes in the coming decades. Nanomedicine aims to overcome some problems related to this prevalent disease, particularly the lack of efficient diagnostic and therapeutic tools. The most recent scientific advances, which have conducted to a more personalized medicine, were focused on the production of nanocarriers involved into the transport and the delivery of drugs to targeted cells. A wide variety of nanocarriers composed by different materials have been designed for their use as drug delivery systems. Polysaccharides have emerged as very useful biopolymers among all raw materials used in the preparation of these nanoplatforms. They are highly stable, non-toxic and biodegradable molecules, and also present some chemical properties which are very difficult to reproduce using artificial polymers. Anionic polymers, such as hyaluronic acid, heparin or alginate, present some structural and chemical characteristics which make them ideal polymers to prepare nanosystems with anticancer applications. This review will focus on the description of some anionic polysaccharides and the possibilities they offer towards the preparation of nanosystems with applications in cancer treatment and diagnostics.

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“…The product exhibited surface activity comparable to Triton X-100 and, additionally, it is non-toxic against human dermal fibroblast and human leukemic cell lines. The synthesis route employing LMP with activation in aqueous medium via EDC was also followed by Tang et al (2010). They used this method to form pectin amide with adriamycin, a drug employed in treating different types of solid malignant tumors.…”

Section: Heteroatom Transformation At the Carboxylic Acid Group Formation Of Amidementioning

confidence: 99%

Chemical modification of pectin and polygalacturonic acid: A critical review

Würfel

Geitel

et al. 2021

BioRes

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Pectin, as a sustainable biopolymer with its two complementary functionalities (carboxyl and hydroxyl moieties) imparted in the α-1,4-galacturonic acid repeating unit, has gained increasing attention in the last few years. The interest in this ubiquitously occurring plant originating polysaccharide (PS) has shifted slowly from applications as a food additive to a broader range of potential applications in medicine, cosmetics, and other industries. Due to the increasing interest in alternatives for petrochemical materials, PSs as biomaterials have gained increasing attention in industrial processes in general. In the last decade, an increasing number of chemical transformations related to pectin have been published, and this is a prerequisite for the design of the structure and hence properties of novel biopolymer-based materials. This work aims to review the chemical modifications of pectin by covalent linkage of the last decade and analyze the materials obtained with these chemical methods critically.

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Synthesis, characterization, and in vitro and in vivo evaluation of a novel pectin–adriamycin conjugate

Cited by 21 publications

References 39 publications

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

Chemical modification of pectin and polygalacturonic acid: A critical review

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