Synthesis, characterization and in vitro bioactivity of sol-gel-derived SiO2–CaO–P2O5–MgO bioglass

Saboori, Abdollah; Rabiee, Mohammad; Moztarzadeh, F.; Sheikhi, Mohammad Hossein; Tahriri, Mohammadreza; Karimi, Meysam

doi:10.1016/j.msec.2008.07.004

Cited by 220 publications

(110 citation statements)

References 43 publications

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“…Some authors suggest Zn 2+ can adopt a tetrahedral coordination and copolymerize with [SiO 4 ] tetrahedra, inducing complexation of the silicate network, which will decrease ion dissolution and delay HCA formation 52,55 . Other authors propose that the Mg 2+ and Zn 2+ ions can reduce the nucleation rate of apatite in solution and then bind to the surface of apatite crystals and delay the crystallization of amorphous apatite 54,[59][60][61][62] . Since Co 2+ has similar properties and seems to behave as Mg 2+ and Zn 2+ in the silicate network, it is possible that it has the same effect on HCA crystallization.…”

Section: Bioactivity Of and Hca Formation On The Bioactive Glassesmentioning

confidence: 99%

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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The cellular response to hypoxia is vital for skeletal tissue development and regeneration. Numerous processes, including progenitor cell recruitment, proliferation and differentiation, are activated through the hypoxia pathway in a low oxygen pressure environment. Novel materials-based strategies designed to activate the hypoxia pathway are therefore of great interest for orthopaedic tissue engineering.Here resorbable bioactive glasses (BG) were designed to activate the hypoxia pathway by substitution of Co 2+ for Ca 2+ in the BG and substitution of Co 2+ and Ca 2+ /+2Na + for Si 4+ . This allowed for the controlled release of cobalt, whilst controlling BG bioactivity (apatite-forming ability). Two series of soda-lime-phosphosilicate glasses were manufactured with increasing concentrations of cobalt. Compositions were calculated to maintain constant network connectivity (2.13) by considering cobalt as an intermediate oxide in the first series, and as a network modifier in the second series. Mg 2+ and Zn 2+ were added to one of the Co 2+ -containing glasses to inhibit HCA formation since delay or inhibition of HCA formation is essential for the use of BG in soft tissues, as is the case of cartilage.Cobalt was present in both the silicate and phosphate phases of the BG. In addition, evidence was found for it playing a dual role in the silicate phase, acting as both an intermediate oxide and taking part in the network as well as being a network modifying oxide. Consistent with an intermediate oxide role, the presence of cobalt in the BG was shown to decrease ion release. HCA formation was delayed with cobalt additions. Mg 2+ and Zn 2+ further delayed HCA formation.Cobalt release was found to be proportional to cobalt content of the BGs enabling the controlled delivery of cobalt in therapeutic active doses.

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Section: Bioactivity Of and Hca Formation On The Bioactive Glassesmentioning

confidence: 99%

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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“…Formation of hydroxyapatite was only observed on the WPC surface. The surface of WPC after reaction with SBF is seen to support a particle deposit of similar morphology to the apatite layer reported to www.scienceasia.org form on bioactive material [27][28][29] . The higher magnification SEM micrograph shows that small particles of an apatite formed as agglomerates (Fig.…”

Section: Bioactivity In Vitromentioning

confidence: 63%

Untitled

Torkittikul¹,

Chaipanich²

2009

ScienceAsia

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Biomaterials containing calcium silicate have been widely used in dental and bone repaired applications. This study investigated mechanical and in vitro biological properties of ordinary and white Portland cement both of which are composed mainly of calcium silicates. The time of setting was determined using a Vicat needle. Compressive strength was measured at the age of 1, 3, and 7 days. The 1 day set Portland cement pastes were soaked in a simulated body fluid to investigate the ability of the material to form a bond with living bone tissue. X-ray diffraction traces of samples following immersion in simulated body fluid demonstrated that both cement pastes form a hydroxyapatite layer within 7 days but white Portland cement shows a noticeably higher amount of apatite crystal than that of ordinary Portland cement. Scanning electron micrographs reveal a clear presence of hydroxyapatite on the surface of white, but not in ordinary Portland cement. In addition, white Portland cement can achieve a compressive strength of 30 MPa within 24 h after curing in distilled water at human temperature.

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“…THERMAL ANALYSIS Figure 3(a) and 3(b) shows the TGA and DTA analysis for sol-gel glass powder after thermal stabilized at 600°C, respectively. There were four stages of weight losses were observed where the first stage occurred at temperature range between 40°C to 100°C due to the removal of absorbed water and pore liquor as associated to the endothermic peak in DTA at 60°C (Bizari et al 2013;Jones et al 2006;Mozafari et al 2010;Mukundan et al 2013;Saboori et al 2009;. The second mass loss has occurred at temperature between 100°C to 600°C in which exothermic peak at 260°C indicated that chemically absorbed water was released (Mukundan et al 2013).…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Macroporous Bioactive Glass Ceramic made via Sol-Gel Route and Powder Sintering Method

Adam¹,

Shamsudin²,

Zainuddin³

et al. 2018

JSM

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Synthesis, characterization and in vitro bioactivity of sol-gel-derived SiO2–CaO–P2O5–MgO bioglass

Cited by 220 publications

References 43 publications

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Untitled

Preparation and Characterization of Macroporous Bioactive Glass Ceramic made via Sol-Gel Route and Powder Sintering Method

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