Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine

Ronconi, Luca; Marzano, Christine; Russo, Umberto; Sitran, S.; Graziani, R.; Fregona, Dolores

doi:10.1016/s0162-0134(02)00465-8

Cited by 41 publications

(28 citation statements)

References 43 publications

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“…[1 -4]. During the past few decades, pharmaceutical properties of organotin(IV) carboxylates have been investigated for their anti-tumour activity [5][6][7][8][9]. Generally, the toxicity of organotin(IV) complexes is influenced by the structure of the ligand and its ability to coordinate and the order of toxicity is R 3 SnR 0 .…”

Section: Introductionmentioning

confidence: 99%

Spectral analysis andin vitrocytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

Khan

Baloch

Ashfaq

2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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Six novel triorganotin(IV) 2-maleimidopropanoato complexes: R 3 SnOCOCH 3 (CH)(COCH) 2 , (R: Me(1), Et(2), n-Pr(3), nBu(4), Ph(5), Bz(6) have been synthesized. Their solid-state configuration has been determined by FT IR and 119m Sn Mö ssbauer spectroscopy. The tin(IV) atom is five-coordinated in all the complexes with 2-maleimidopropanoic acid behaving as a monoanionic bidentate ligand coordinating the tin(IV) atom through a chelating or bridging carboxylate group. The solution-state configuration has been elucidated by means of 1 H-, 13 C-and 119 Sn-NMR spectroscopy which assigned a tetrahedron. Elemental analysis and FAB MS data also supported a 1:1 metal to ligand stoichiometry. The title complexes have been screened in vitro for anti-tumour, anti-fungal, anti-leishmanial and urease inhibition activities and displayed promising results.

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Section: Introductionmentioning

confidence: 99%

Spectral analysis andin vitrocytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

Khan

Baloch

Ashfaq

2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…In order to get the 100% and IC 50 mortality concentration, serial dilutions of the test compounds were performed in 96-well microtiter plate. Subsequently, 10 5 promastigotes in 100 µl of culture medium were added to each well and the plate was incubated at 25…”

Section: Viability Testmentioning

confidence: 99%

Synthesis, characterization and in vitro cytotoxic effects of new organotin(IV)‐2‐maleimidopropanoates

Khan¹,

Baloch²,

Ashfaq³

et al. 2006

Applied Organom Chemis

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“…Numerous organotin compounds, which exhibit a variety of biological properties, have been synthesized and described in the literature [2,3]. The biocidal applications of organotin compounds include their implication in acute poisoning in humans [4] and animals [5,6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and crystal structure of bis(acetylacetonato)dichlorotin(IV)

Shahzadi

Ali

Jin

2006

JICS

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The compound bis(acetylacetonato)dichlorotin(IV) [Sn(acac) 2 Cl 2 ] forms a distorted octahedral structure involving both oxygen atoms of the acetylacetone group. The two chlorides occupy the cis position, with Sn-Cl distances of Sn1-Cl1 = 2.380(2) Å, Sn1-O1 = 2.043(2) Å and Sn1-O2 = 2.093(2) Å. We report here a new and simple method for the synthesis of Sn(acac) 2 Cl 2 , its spectroscopic characterization and, for the first time, we report its crystal structure.

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Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine

Cited by 41 publications

References 43 publications

Spectral analysis andin vitrocytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

Spectral analysis andin vitrocytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

Synthesis, characterization and in vitro cytotoxic effects of new organotin(IV)‐2‐maleimidopropanoates

Synthesis, characterization and crystal structure of bis(acetylacetonato)dichlorotin(IV)

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