Synthesis, characterization and in vitro anti-proliferative effects of pentacyclic triterpenoids

Synthesis and Antimicrobial Activity Evaluation of Pyridine Derivatives Containing Imidazo[2,1‐b][1,3,4]Thiadiazole Moiety

“…The synthetic route of 2-cyclopropyl-6-(2,4-difluorophenyl)imidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (13) was shown in Scheme 1. 5-Cyclopropyl-1,3,4-thiazol-2-amine (11) was synthesized by cyclization of cyclopropane carboxylic acid (9) and thiosemicarbazide in the presence of POCl 3 in 98 % yield.…”

Synthesis and Antibacterial Activity Evaluation of Imidazole Derivatives Containing 6‐Methylpyridine Moiety

“…In a review of the literature, compounds containing imidazo [2,1-b] [1,3,4]thiadiazole structure are reported to show a variety of biological activities, such as antibacterial, [4][5][6][7][8][9][10] anti-inflammatory, [11 -14] anticonvulsant, [15 -18] antifungal, [19 -22] antituberculosis, [23][24][25][26] anti-cancer, [27][28][29][30][31] anesthesia, and diuresis activities. [32] Hakan et al [33] synthesized a series of phenyl-substituted imidazo[2,1b] [1,3,4]thiadiazole derivatives and evaluated for their antibacterial and antifungal activities.…”

“…The requisite 1-(2-cyclopropyl-6-phenylimidazo[2,1b] [1,3,4]thiadiazol-5-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (13) was synthesized as shown in Scheme 1. 5-Cyclopropyl-1,3,4-thiadiazol-2-amine (9) was prepared by cyclization of cyclopropane carboxylic acid (8) and thiosemicarbazide in presence of POCl 3 in 65 % yield.…”

“…In a review of the literature, compounds containing imidazo[2,1‐ b ][1,3,4]thiadiazole structure are reported to show a variety of biological activities, such as antibacterial, [4–10] anti‐inflammatory, [11–14] anticonvulsant, [15–18] antifungal, [19–22] anti‐tuberculosis, [23–26] anti‐cancer, [27–31] anesthesia, and diuresis activities [32] . Hakan et al [33] .…”

Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing the imidazo[2,1‐b][1,3,4]thiadiazole moiety

“…Since then, it has been widely studied in medicinal chemistry. Most ITD derivatives have been reported to exhibit a variety of biological activities, such as antibacterial, [22][23][24][25][26][27][28][29] antifungal, [30][31][32][33] anticancer, [34][35][36][37][38][39] anti-inflammatory, [40][41][42][43] and anticonvulsant activities. [44][45][46] In the study of pyrazole compounds, it was found that pyrazole is also a good antifungal activity of the structure, such as compounds 2 (Candida albicans, minimum inhibitory concentration [MIC] = 0.12 μg/mL), [47] 3 (C. albicans, MIC = 1.262 μM), [48] 4 (C. albicans, EC 50 = 50 nM), [48] and 5 (C. albicans, EC 50 = 117 nM).…”